INT12424

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 48
Total Number 49
Disease Relevance 8.23
Pain Relevance 24.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
brain 4
synovial fluid 2
plasma 2
middle cerebral artery 2
sympathetic 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 125 100.00 Very High Very High Very High
Cholecystokinin 25 100.00 Very High Very High Very High
Opioid 21 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Catecholamine 17 100.00 Very High Very High Very High
narcan 17 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Neuropathic pain 9 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
Endogenous opioid 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 17 100.00 Very High Very High Very High
Urological Neuroanatomy 9 99.28 Very High Very High Very High
Lordosis 3 99.08 Very High Very High Very High
Nervous System Injury 2 98.80 Very High Very High Very High
Open Bite 1 98.62 Very High Very High Very High
Pain 22 98.08 Very High Very High Very High
Middle Cerebral Artery Infarction 10 97.76 Very High Very High Very High
Ganglion Cysts 9 97.48 Very High Very High Very High
Appetite Loss 7 94.96 High High
Increased Venous Pressure Under Development 2 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions between neuropeptide Y and alpha 2-adrenoceptors in selective rat brain regions.
neuropeptide Y Binding (Interactions) of in brain associated with neuropeptide
1) Confidence 0.48 Published 1991 Journal Peptides Section Title Doc Link 1647005 Disease Relevance 0.09 Pain Relevance 0.47
NPY, perhaps acting via Y1/Y5 receptors, might profoundly influence the processing of NP information and interact with the endogenous opioid system primarily within the framework of the VLPAG.
NPY Spec (might) Binding (interact) of associated with endogenous opioid and neuropathic pain
2) Confidence 0.48 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19556004 Disease Relevance 0.72 Pain Relevance 1.89
The importance of NPY/alpha 2 receptor-receptor interactions in cardiovascular, neuroendocrine and vigilance control is emphasized.
NPY Binding (interactions) of
3) Confidence 0.48 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2159745 Disease Relevance 0.16 Pain Relevance 0.11
An additional explanation is the possibility that the interaction between CCK, NPY and adrenaline takes place at the network level.
NPY Binding (interaction) of associated with cholecystokinin
4) Confidence 0.47 Published 1986 Journal J Hypertens Suppl Section Abstract Doc Link 3475413 Disease Relevance 0.08 Pain Relevance 0.53
In contrast, when NPY(13-36) (300 nM), a selective NPY Y2 receptor agonist, was used to block the binding to NPY Y2 receptors, clonidine (1-30 nM) did not affect the B0 value and the IC50 value of NPY(1-36) when competing for [125I]PYY-binding sites, suggesting that the stimulation of alpha 2 receptors can selectively increase the affinity of NYP(1-36) for the NPY Y2 receptor.
NPY Binding (binding) of associated with agonist and clonidine
5) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982085 Disease Relevance 0 Pain Relevance 0.48
Focus on volume transmission and neuropeptide Y/alpha 2 receptor interactions.
neuropeptide Y Binding (interactions) of associated with neuropeptide
6) Confidence 0.47 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 2159745 Disease Relevance 0.16 Pain Relevance 0.15
In other studies, intake of standard chow after NPY stimulation can be blocked by naloxone, indicating an interaction between these systems in the regulation of feeding.
NPY Binding (interaction) of associated with narcan
7) Confidence 0.37 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8760223 Disease Relevance 0.07 Pain Relevance 0.62
These results indicate that NPY can increase the sensitivity of the alpha 2-autoreceptors belonging to hypothalamic NA and/or to adrenaline nerve terminals and to cortical NA nerve terminals, while the alpha 2-heteroreceptors inhibiting 3H-HT release in the same brain regions appear not to be regulated by high affinity NPY receptors.
NPY Binding (affinity) of in brain
8) Confidence 0.37 Published 1989 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 2754431 Disease Relevance 0 Pain Relevance 0.44
Anterior open bite as a clinical sign of joint destruction was found to be associated with high levels of NPY and IL-1beta in the synovial fluid.
NPY Binding (associated) of in synovial fluid
9) Confidence 0.37 Published 1998 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 9461143 Disease Relevance 0.21 Pain Relevance 0
Intracisternal injections of galanin and NPY were performed 2 weeks after nerve injury and mechanical allodynia was monitored.
NPY Binding (injections) of in nerve associated with nervous system injury and allodynia
10) Confidence 0.37 Published 2009 Journal Int. J. Neurosci. Section Abstract Doc Link 19922394 Disease Relevance 0.60 Pain Relevance 0.67
Immunoreactivity to neuropeptide Y, vasoactive intestinal polypeptide and nitric oxide synthase was similar in tissue sections taken from capsaicin-treated rats and those taken from control tissues.
neuropeptide Y Binding (Immunoreactivity) of associated with qutenza and neuropeptide
11) Confidence 0.36 Published 1998 Journal Neuroscience Section Abstract Doc Link 9460767 Disease Relevance 0.08 Pain Relevance 0.62
receptor, NPYR6 receptor, preproenkephalin, and ?
NPY Binding (receptor) of
12) Confidence 0.36 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0 Pain Relevance 0.17
The NPY-alpha-1 interaction in stimulating plasma OT was not mediated by direct binding of the peptides to alpha-1-adrenergic receptor sites.
NPY Binding (interaction) of in plasma
13) Confidence 0.36 Published 1993 Journal Endocrinology Section Abstract Doc Link 8381069 Disease Relevance 0 Pain Relevance 0.31
Recent studies have shown increased immunoreactivity for neuropeptide Y (NPY) within the perilesional cortex following experimental middle cerebral artery occlusion (MCAO) or focal excitotoxic damage.
NPY Binding (immunoreactivity) of in middle cerebral artery associated with middle cerebral artery infarction and neuropeptide
14) Confidence 0.36 Published 2002 Journal Brain Res. Section Abstract Doc Link 11821007 Disease Relevance 0.48 Pain Relevance 0.13
Recent studies have shown increased immunoreactivity for neuropeptide Y (NPY) within the perilesional cortex following experimental middle cerebral artery occlusion (MCAO) or focal excitotoxic damage.
neuropeptide Y Binding (immunoreactivity) of in middle cerebral artery associated with middle cerebral artery infarction and neuropeptide
15) Confidence 0.36 Published 2002 Journal Brain Res. Section Abstract Doc Link 11821007 Disease Relevance 0.47 Pain Relevance 0.12
Modulatory interactions of neuropeptide Y (NPY) on sympathetic neurotransmission.
neuropeptide Y Binding (interactions) of in sympathetic associated with neuropeptide
16) Confidence 0.36 Published 1989 Journal Acta Physiol Scand Suppl Section Title Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.18
Modulatory interactions of neuropeptide Y (NPY) on sympathetic neurotransmission.
NPY Binding (interactions) of in sympathetic associated with neuropeptide
17) Confidence 0.36 Published 1989 Journal Acta Physiol Scand Suppl Section Title Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.18
These results demonstrate a reciprocal potentiation of NPY and alpha 2 agonists in the brainstem, and suggest that NPY and catecholamines interact in central cardiovascular regulation.
NPY Binding (interact) of in brainstem associated with medulla, catecholamine and agonist
18) Confidence 0.36 Published 1991 Journal Proc. Natl. Sci. Counc. Repub. China B Section Abstract Doc Link 1658840 Disease Relevance 0 Pain Relevance 0.50
Furthermore, the neuropeptide Y-induced increases in hindpaw withdrawal latency were attenuated by following intra-nucleus raphe magnus injection of 6 nmol of the opioid antagonist naloxone, indicating that there is an interaction between NPY and opioids in nucleus raphe magnus.
NPY Binding (interaction) of in nucleus associated with raphe magnus, antagonist, narcan, neuropeptide, opioid and withdrawal
19) Confidence 0.35 Published 2000 Journal Regul. Pept. Section Abstract Doc Link 11062340 Disease Relevance 0.07 Pain Relevance 0.93
In the second study dealing with the possible synergistic or additive interactions between NPY and NE, we observed that when doses of NPY and NE that separately were only minimally effective in stimulating LH release were administered together, the amounts of LH secreted were greater than the sum of the individual responses.
NPY Binding (interactions) of
20) Confidence 0.35 Published 1987 Journal Endocrinology Section Abstract Doc Link 2824175 Disease Relevance 0 Pain Relevance 0.66

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