INT124253

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
skin 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 40 93.68 High High
adenocard 1 81.92 Quite High
Inflammation 38 68.12 Quite High
Pain 16 67.44 Quite High
Potency 2 67.36 Quite High
addiction 35 50.00 Quite Low
Thermal hyperalgesia 18 50.00 Quite Low
Antinociceptive 1 31.92 Quite Low
Morphine 6 28.88 Quite Low
cocaine 6 28.08 Quite Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 1 89.36 High High
Targeted Disruption 42 87.60 High High
INFLAMMATION 39 68.12 Quite High
Pain 15 67.44 Quite High
Cancer 3 63.04 Quite High
Sprains And Strains 3 59.68 Quite High
Hyperalgesia 33 50.00 Quite Low
Body Weight 2 41.68 Quite Low
Growth Hormone Deficiency 1 38.00 Quite Low
Inflammatory Pain 17 25.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excision of exon 10 from Creb1 leads to translation of CREB deficient in DNA binding and dimerization functional domains, such that the protein is unstable and thus, there is loss of CREB [68].
Negative_regulation (deficient) of CREB Binding (binding) of
1) Confidence 0.42 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.15 Pain Relevance 0
In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.
Negative_regulation (abrogated) of CREB Binding (binding) of in skin
2) Confidence 0.37 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.31 Pain Relevance 0.16
In addition, the NO signaling pathway can mediate the expression of CREB target genes by controlling CREB-DNA binding, which is independent of CREB phosphorylation [62].
Neg (independent) Negative_regulation (independent) of CREB-DNA Binding (binding) of
3) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.29 Pain Relevance 0.16

General Comments

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