INT124256

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
skin 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 10 92.24 High High
antidepressant 8 76.00 Quite High
Inflammation 4 68.60 Quite High
Pain 1 67.92 Quite High
Desipramine 4 63.72 Quite High
tricyclic antidepressant 2 55.56 Quite High
depression 6 52.16 Quite High
COX2 1 25.00 Low Low
Eae 14 16.28 Low Low
Nucleus accumbens 10 9.96 Low Low
Disease Link Frequency Relevance Heat
Convulsion 20 99.56 Very High Very High Very High
Shock 6 83.60 Quite High
Targeted Disruption 48 77.60 Quite High
Epilepsy 12 75.36 Quite High
Stress 22 73.20 Quite High
Status Epilepticus 6 72.56 Quite High
INFLAMMATION 3 68.60 Quite High
Pain 1 67.92 Quite High
Cancer 1 63.52 Quite High
Depression 6 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.
Positive_regulation (induced) of CREB Binding (binding) of in skin
1) Confidence 0.40 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.31 Pain Relevance 0.16
CRE binding of CREB is transiently upregulated after kindling stimulation [73].
Positive_regulation (upregulated) of CREB Binding (binding) of
2) Confidence 0.38 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.96 Pain Relevance 0.23
However, the outcome of CRE-mediated gene transcription does not solely depend on CREB binding, but on the competitive binding of several dimerized transcription factors, including activators and repressors of gene transcription.
Neg (not) Positive_regulation (depend) of CREB Binding (binding) of
3) Confidence 0.27 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0

General Comments

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