INT124256

Context Info Confidence 0.40 First Reported 2005 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.27 Pain Relevance 0.39

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)

Anatomy Link Frequency skin 2 Creb1 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 10 92.24 antidepressant 8 76.00 Inflammation 4 68.60 Pain 1 67.92 Desipramine 4 63.72 tricyclic antidepressant 2 55.56 depression 6 52.16 COX2 1 25.00 Eae 14 16.28 Nucleus accumbens 10 9.96

Disease Link Frequency Relevance Heat Convulsion 20 99.56 Shock 6 83.60 Targeted Disruption 48 77.60 Epilepsy 12 75.36 Stress 22 73.20 Status Epilepticus 6 72.56 INFLAMMATION 3 68.60 Pain 1 67.92 Cancer 1 63.52 Depression 6 52.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.

Positive_regulation (induced) of CREB Binding (binding) of in skin

1) Confidence 0.40 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.31 Pain Relevance 0.16

CRE binding of CREB is transiently upregulated after kindling stimulation [73].

Positive_regulation (upregulated) of CREB Binding (binding) of

2) Confidence 0.38 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.96 Pain Relevance 0.23

However, the outcome of CRE-mediated gene transcription does not solely depend on CREB binding, but on the competitive binding of several dimerized transcription factors, including activators and repressors of gene transcription.

Neg (not) Positive_regulation (depend) of CREB Binding (binding) of

3) Confidence 0.27 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0

General Comments

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