INT124257

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 24
Disease Relevance 3.33
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) peptidase activity (Plat) extracellular space (Plat)
extracellular region (Plat) nucleus (Jun) DNA binding (Jun)
Anatomy Link Frequency
HT-29 1
macrophage 1
Plat (Mus musculus)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 42 86.40 High High
Inflammation 138 86.00 High High
Pain 4 74.16 Quite High
cINOD 20 47.60 Quite Low
COX2 4 25.00 Low Low
metalloproteinase 60 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 86 98.74 Very High Very High Very High
Breast Cancer 60 94.64 High High
Necrosis 2 90.28 High High
Stress 82 88.16 High High
INFLAMMATION 158 86.00 High High
Apoptosis 92 82.40 Quite High
Skin Cancer 42 81.32 Quite High
Pain 4 74.16 Quite High
Disease 60 64.08 Quite High
Coronary Artery Disease 2 42.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.
TPA Positive_regulation (activation) of AP-1
1) Confidence 0.12 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.34 Pain Relevance 0.17
While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.
TPA Positive_regulation (activation) of activator protein-1
2) Confidence 0.12 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.34 Pain Relevance 0.17
Inhibition or enhancement of the TPA-induced activation of AP-1 by methoxy-substituted trans-stilbenes
TPA Positive_regulation (activation) of AP-1
3) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by analogs of trans-stilbenes
TPA Positive_regulation (activation) of AP-1
4) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by resveratrol and phenolic trans-stilbenes
TPA Positive_regulation (activation) of AP-1
5) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by para-methoxy-substituted trans-stilbenes
TPA Positive_regulation (activation) of AP-1
6) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
In HT-29 cancer cells transfected with an AP-1 reporter, resveratrol enhanced AP-1 activity induced by TPA, similar to the present study [30].
TPA Positive_regulation (induced) of AP-1 in HT-29 associated with cancer
7) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.38 Pain Relevance 0
We report here that substituted trans-stilbenes devoid of anti-oxidant activity can function as inhibitors of the TPA-induced activation of AP-1.
TPA Positive_regulation (activation) of AP-1
8) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.07 Pain Relevance 0
Resveratrol and 7 trans-stilbenes that contained one or more phenolic substituents were compared for their effects on the TPA-induced activation of AP-1 in an initial screening at 15 ?
TPA Positive_regulation (activation) of AP-1
9) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Several trans-stilbenes were identified that inhibit TPA-induced activation of AP-1, with IC50 values as low as 0.5 ?
TPA Positive_regulation (activation) of AP-1
10) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2632638 Disease Relevance 0.31 Pain Relevance 0.08
Assay of the activities of substituted trans-stilbeness as inhibitors of the TPA-induced activation of AP-1
TPA Positive_regulation (activation) of AP-1
11) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
None of the trans-stilbenes in this group enhanced the TPA-induced activation of AP-1.
TPA Positive_regulation (activation) of AP-1
12) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
LMD directed the synthetic chemistry and helped design the study; LAH and AMG collected the data related to the effects of substituted trans-stilbenes on TPA-induced activation of AP-1; RAO designed and directed studies involving use of macrophage cells; and DLVJ helped design the study and wrote the manuscript.



TPA Positive_regulation (activation) of AP-1 in macrophage
13) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.05 Pain Relevance 0
Clearly, structures of inhibitors or enhancers of the TPA-induced activation of AP-1 can differ considerable from a strict trans-stilbene scaffold.


TPA Positive_regulation (activation) of AP-1
14) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.11 Pain Relevance 0.06
Moreover, some trans-stilbenes can function as enhancers of the TPA-induced activation of AP-1.


TPA Positive_regulation (activation) of AP-1
15) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.07 Pain Relevance 0
Some of these trans-stilbenes, such as 8, 9, 10and 11, were strong inhibitors of the TPA-induced activation of AP-1 with IC50 values in the range 0.7 to 3.8 ?
TPA Positive_regulation (activation) of AP-1
16) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
In the present study, a library of substituted trans-stilbenes, including polyphenols, was screened for activity against the TPA-induced activation of AP-1 using the Panomics AP-1 Reporter 293 Stable Cell Line, which is designed for screening potential inhibitors or activators.


TPA Positive_regulation (activation) of AP-1
17) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2632638 Disease Relevance 0.34 Pain Relevance 0.09
Substituted trans-stilbenes represent a class of compounds that can inhibit or enhance the TPA-induced activation of AP-1.
TPA Positive_regulation (activation) of AP-1
18) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.40 Pain Relevance 0.04
In the present study, a library of substituted trans-stilbenes was examined for activity as inhibitors or activators of the TPA-induced activation of AP-1 in the Panomics AP-1 Reporter 293 Stable Cell Line, which is the HEK293 cell transfected with an AP-1-dependent luciferase construct.
TPA Positive_regulation (activation) of AP-1
19) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.14 Pain Relevance 0.03
In this series, many compounds were strong inhibitors of the TPA-induced activation of AP-1, such as 46, 47, 48, 49and 51(Table 1).
TPA Positive_regulation (activation) of AP-1
20) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0

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