INT124262

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Plat, Mapk1) nucleoplasm (Mapk1) mitochondrion (Mapk1)
protein complex (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Plat (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 87.44 High High
Pain 1 86.76 High High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 87.44 High High
Pain 1 86.76 High High
Cancer 1 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an underlying mechanism of COX-2 inhibition, these extracts diminished TPA-stimulated catalytic activity of extracellular signal-regulated protein kinase (ERK), which is known to regulate the activation of eukaryotic transcription factors mediating COX-2 induction.
Negative_regulation (diminished) of TPA Positive_regulation (stimulated) of ERK
1) Confidence 0.13 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.41 Pain Relevance 0.21

General Comments

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