INT124264

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.39
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sciatic nerve 2
nerve 2
sensory nerve 2
skin 2
hearts 2
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 36 100.00 Very High Very High Very High
calcitonin gene related peptide 35 100.00 Very High Very High Very High
Morphine 250 99.98 Very High Very High Very High
substance P 18 99.90 Very High Very High Very High
Serotonin 26 98.68 Very High Very High Very High
unmyelinated 5 98.32 Very High Very High Very High
Sciatic nerve 4 98.14 Very High Very High Very High
narcan 33 97.72 Very High Very High Very High
bradykinin 59 95.32 Very High Very High Very High
Adelta 1 94.68 High High
Disease Link Frequency Relevance Heat
Nociception 66 98.52 Very High Very High Very High
INFLAMMATION 46 94.52 High High
Pain 87 92.08 High High
Coronary Artery Disease 3 91.52 High High
Ganglion Cysts 30 85.76 High High
Targeted Disruption 50 76.24 Quite High
Cancer Pain 1 64.48 Quite High
Bone Cancer 1 64.28 Quite High
Diabetes Mellitus 6 61.52 Quite High
Peripheral Neuropathy 2 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noxious heat-induced calcitonin gene-related peptide release showed clear deficits (<50%) in TRPV1 deficient skin, but the stimulated calcitonin gene-related peptide release from the isolated skull dura was unaffected.
Neg (unaffected) Regulation (unaffected) of Localization (release) of calcitonin in skin associated with calcitonin gene-related peptide
1) Confidence 0.33 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165301 Disease Relevance 0.07 Pain Relevance 0.55
A separate series of experiments was performed to test the hypothesis that morphine concentrations without a direct effect on CGRP release may sensitize cutaneous afferents to noxious stimuli activating TRPV1 or TRPA1.
Neg (without) Regulation (effect) of Localization (release) of CGRP associated with morphine
2) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0 Pain Relevance 0.88
Morphine concentrations below the activation threshold sensitized TRPV1 and TRPA1 in native cutaneous nerve endings releasing CGRP.
Regulation (sensitized) of Localization (releasing) of CGRP in nerve associated with morphine
3) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0.23 Pain Relevance 1.26
Morphine sensitizes CGRP release induced by acrolein and heat
Regulation (sensitizes) of Localization (release) of CGRP associated with morphine
4) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0 Pain Relevance 0.90
We present evidence that also in isolated mouse sciatic nerve axons the intracellular protein kinase A (PKA)- and C (PKC)-dependent transduction pathways modulate heat-induced (45 degrees C) CGRP release.
Regulation (modulate) of Localization (release) of CGRP in sciatic nerve associated with calcitonin gene related peptide and sciatic nerve
5) Confidence 0.25 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17610576 Disease Relevance 0.08 Pain Relevance 0.57
Role of different proton-sensitive channels in releasing calcitonin gene-related peptide from isolated hearts of mutant mice.
Regulation (Role) of Localization (releasing) of gene-related peptide in hearts associated with calcitonin gene-related peptide
6) Confidence 0.22 Published 2005 Journal Cardiovasc. Res. Section Title Doc Link 15639479 Disease Relevance 0.09 Pain Relevance 0.38
In sensory nerve terminals CGRP release in response to noxious heat can be sensitized by activation of G-protein-coupled receptors and related protein kinases.
Regulation (sensitized) of Localization (release) of CGRP in sensory nerve associated with calcitonin gene related peptide
7) Confidence 0.17 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17610576 Disease Relevance 0.05 Pain Relevance 0.55
Of concern are the maintenance of body temperature, TRPV1-mediated SP and CGRP release and their subsequent effect on the cardiovascular functions and acute nociception.
Regulation (effect) of Localization (release) of CGRP in body associated with nociception, calcitonin gene related peptide and substance p
8) Confidence 0.14 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.73 Pain Relevance 0.84
Serotonin acts on the 5HT1p receptors on the terminals of submucosal IPANs resulting in the secretion of Ach and CGRP by the IPANs. 5HT4 receptors are present pre-synaptically on the distal terminals of submucosal IPANs.
Regulation (resulting) of Localization (secretion) of CGRP associated with calcitonin gene related peptide and serotonin
9) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503665 Disease Relevance 0.09 Pain Relevance 0.68
The basal CGRP release was unaffected by the presence of PAR1-AP.
Neg (unaffected) Regulation (unaffected) of Localization (release) of CGRP associated with calcitonin gene-related peptide
10) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.05 Pain Relevance 0.52

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