INT12429

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Context Info
Confidence 0.20
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.07
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Spdya) cell cycle (Spdya)
Anatomy Link Frequency
cardiac muscle 1
Spdya (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 8 98.28 Very High Very High Very High
tolerance 5 97.96 Very High Very High Very High
Cannabinoid 8 97.60 Very High Very High Very High
Opioid 8 96.20 Very High Very High Very High
agonist 5 95.64 Very High Very High Very High
Clonidine 2 92.92 High High
ischemia 2 81.28 Quite High
antinociception 3 80.24 Quite High
Catecholamine 1 79.52 Quite High
tail-flick 2 69.40 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 5 99.12 Very High Very High Very High
Cirrhosis 61 93.88 High High
Coronary Artery Disease 3 82.16 Quite High
Injury 1 65.52 Quite High
Hypoxia 1 57.92 Quite High
Stress 4 54.72 Quite High
Congenital Anomalies 3 52.64 Quite High
Coronary Heart Disease 12 45.64 Quite Low
Myocardial Infarction 5 36.60 Quite Low
Increased Venous Pressure Under Development 15 35.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of AC by 5'-guanylylimidodiphosphate (GppNHp) and by NaF was also attenuated by treatment with either CCh or methoxamine, indicating reduction of the Gs protein function.
Negative_regulation (reduction) of Gs protein
1) Confidence 0.20 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1647049 Disease Relevance 0.17 Pain Relevance 0.13
This suggests that the stimulation of phosphoinositide hydrolysis elicited by CCh possibly participates in stable muscarinic inhibition of AC presumably by reducing the function of the Gs protein.
Negative_regulation (reducing) of Gs protein
2) Confidence 0.20 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1647049 Disease Relevance 0.14 Pain Relevance 0.10
This cross-talk results from inhibition of the Gs protein and adenylyl cyclase of the beta-AR pathway by the pertussis toxin-sensitive G protein of the opioid pathway.
Negative_regulation (inhibition) of Gs protein associated with bordatella infection and opioid
3) Confidence 0.07 Published 2001 Journal J. Biomed. Sci. Section Abstract Doc Link 11455191 Disease Relevance 0.30 Pain Relevance 0.60
Cannabinoid-induced tolerance is thus associated with a G protein coupling switch from the inhibitory Gi protein to the excitatory Gs protein, an effect which is prevented by the ultra-low dose rimonabant.
Negative_regulation (prevented) of Gs protein associated with cannabinoid and tolerance
4) Confidence 0.04 Published 2007 Journal Behav Pharmacol Section Abstract Doc Link 17989514 Disease Relevance 0 Pain Relevance 0.62
-adrenoceptors signaling pathway is also impaired at different levels, starting with decreased membrane content and function of the stimulatory Gs-protein and ending up with impaired activity of the adenylate cyclase enzyme itself.[33–34]Muscarinic receptor activity: Muscarinic responsiveness was found to be blunted in cirrhotic hearts.[35] Muscarinic receptor stimulation exerts a negative inotropic effect on cardiac muscle counterbalancing the stimulatory ?
Negative_regulation (decreased) of Gs-protein in cardiac muscle associated with cirrhosis
5) Confidence 0.04 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 0.44 Pain Relevance 0.04

General Comments

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