INT124290

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.48
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
bladder 2
dorsal root ganglia 2
mast cells 2
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 24 86.84 High High
Inflammation 11 62.16 Quite High
qutenza 2 50.00 Quite Low
interstitial cystitis 1 46.84 Quite Low
pruritus 1 45.80 Quite Low
antagonist 5 41.92 Quite Low
nud 4 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
allodynia 2 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 46 99.76 Very High Very High Very High
Infection 8 88.84 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

23 86.84 High High
Inflammatory Pain 2 75.04 Quite High
INFLAMMATION 9 68.28 Quite High
Mucositis 2 57.00 Quite High
Cystitis 2 50.00 Quite Low
Disease 1 47.80 Quite Low
Interstitial Cystitis 1 46.84 Quite Low
Pruritus 1 45.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in the present study, we aimed to evaluate whether acute restraint stress alters the numbers of mast cells and EC cells and PAR2 expression in the rat colon.
Spec (whether) Negative_regulation (numbers) of Gene_expression (expression) of PAR2 in mast cells associated with stress
1) Confidence 0.42 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.76 Pain Relevance 0.52
CONCLUSIONS: These studies demonstrate that 1) CYP induced cystitis up-regulates PAR2 to 4 expression in the bladder, 2) PAR2 to 4 is expressed in urothelium, detrusor muscle and bladder nerve fibers in control and CYP treated rats, and 3) bladder C-fibers and bladder afferent cells in dorsal root ganglia express PAR2 to 4.
Negative_regulation (expressed) of Gene_expression (expression) of PAR2 in dorsal root ganglia
2) Confidence 0.36 Published 2005 Journal J. Urol. Section Body Doc Link 15643279 Disease Relevance 0.11 Pain Relevance 0
Immunohistochemistry revealed PAR2 to 4 expression in urothelial and detrusor muscle cells, and in nerve fibers in the subepithelial bladder layer.
Negative_regulation (revealed) of Gene_expression (expression) of PAR2 in bladder
3) Confidence 0.36 Published 2005 Journal J. Urol. Section Body Doc Link 15643279 Disease Relevance 0.14 Pain Relevance 0

General Comments

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