INT124298

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.50
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Anatomy Link Frequency
neuronal 3
poly 1
nucleus 1
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 88.88 High High
anesthesia 6 79.00 Quite High
imagery 2 65.28 Quite High
tolerance 44 54.92 Quite High
Inflammation 26 5.00 Very Low Very Low Very Low
Deafferentation 19 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
ischemia 13 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Potency 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 176 100.00 Very High Very High Very High
Targeted Disruption 81 91.88 High High
Neurodegenerative Disease 52 89.56 High High
Drug Induced Neurotoxicity 5 83.88 Quite High
Death 68 79.48 Quite High
Stress 61 78.88 Quite High
Aging 6 73.04 Quite High
Disease 140 65.72 Quite High
Dilated Cardiomyopathy 5 34.36 Quite Low
Fatty Liver 2 33.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, the siRNA knocked down the abundance of SOD2 as indicated by the decreased levels of the protein (Figures 1D and S1B), mRNA (Figures 1E and S1C), and enzyme activity (Figure 1F).
Localization (abundance) of SOD2
1) Confidence 0.74 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.31 Pain Relevance 0
Such aberrant mitochondrial localization was accompanied by decreased mitochondrial manganese superoxide dismutase (Mn-SOD) activity, cytochrome c release into the cytosol, caspase-3 activation, and DNA fragmentation, most predominantly in hippocampal neuronal cells.
Localization (release) of Mn-SOD in neuronal
2) Confidence 0.62 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644272 Disease Relevance 0.61 Pain Relevance 0.08
Such aberrant mitochondrial localization was accompanied by decreased mitochondrial manganese superoxide dismutase (Mn-SOD) activity, cytochrome c release into the cytosol, caspase-3 activation, and DNA fragmentation, most predominantly in hippocampal neuronal cells.
Localization (localization) of manganese superoxide dismutase in neuronal
3) Confidence 0.61 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644272 Disease Relevance 0.63 Pain Relevance 0.08
4) NT: performed breeding of MnSOD+/- mice
Localization (breeding) of MnSOD
4) Confidence 0.55 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.06 Pain Relevance 0.03
Such aberrant mitochondrial localization was accompanied by decreased mitochondrial manganese superoxide dismutase (Mn-SOD) activity, cytochrome c release into the cytosol, caspase-3 activation, and DNA fragmentation, most predominantly in hippocampal neuronal cells.
Localization (release) of manganese superoxide dismutase in neuronal
5) Confidence 0.54 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644272 Disease Relevance 0.61 Pain Relevance 0.08
with primary antibodies (poly [ADP-ribose] PAR, Trevigen, Gaithersburg, MD, USA; caspase 3, Cell Signaling Technology, Beverly, MA, USA; mitochondrial manganese superoxide dismutase (MnSOD), Stressgen, Ann Arbor, MI, USA; Bcl-2 and Bax, Santa Cruz Biotechnology, Santa Cruz, CA, USA, diluted 1:1,000, respectively).
Localization (manganese) of MnSOD in poly
6) Confidence 0.35 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.34 Pain Relevance 0.03
Phosphorylation and degradation of IkB, the inhibitory subunit that sequesters the NF-kB complex in the cytoplasm, releases NF-kB which can traslocate to the nucleus and activate the transcription of genes that promote resistance to apoptosis, such as MnSOD, Bcl-2 and members of the Inhibitor of Apoptosis Proteins (IAPs) family.
Localization (traslocate) of MnSOD in nucleus associated with apoptosis
7) Confidence 0.14 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.93 Pain Relevance 0.08
Chemical UL-induced change in MnSOD immunoreactivity in the vestibular nuclei
Localization (change) of MnSOD
8) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0 Pain Relevance 0

General Comments

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