INT1243

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Context Info
Confidence 0.54
First Reported 1976
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 1.84
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
Anatomy Link Frequency
A431 3
platelets 2
plasma 1
muscle 1
brain 1
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 33 100.00 Very High Very High Very High
Catecholamine 11 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
antagonist 22 99.96 Very High Very High Very High
IPN 6 99.82 Very High Very High Very High
cocaine 3 99.68 Very High Very High Very High
opiate 2 99.44 Very High Very High Very High
adenocard 2 98.30 Very High Very High Very High
withdrawal 5 98.24 Very High Very High Very High
Clonidine 25 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 6 98.80 Very High Very High Very High
Thrombosis 1 98.48 Very High Very High Very High
Squamous Cell Carcinoma 3 98.16 Very High Very High Very High
Personality Disorder 2 95.88 Very High Very High Very High
Retinoblastoma 6 82.24 Quite High
Bordatella Infection 3 81.12 Quite High
Lifespan 5 79.12 Quite High
Aggression 1 78.28 Quite High
Neuroblastoma 2 75.00 Quite High
Heart Rate Under Development 2 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic opioid regulation of stimulatory beta-2 adrenoceptor (beta-2 AR) signaling was investigated in human mammary epidermoid carcinoma A431 cells stably expressing the cloned rat mu opioid receptor.
Regulation (regulation) of beta-2 adrenoceptor in A431 associated with squamous cell carcinoma, mu opioid receptor and opioid
1) Confidence 0.54 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996236 Disease Relevance 0.10 Pain Relevance 0.41
Regulation of human beta 2-adrenergic receptors in lymphocytes (determined by (+/-)-125iodocyanopindolol (ICYP) binding) and alpha 2-adrenergic receptors in platelets (determined by 3H-yohimbine binding) was studied.
Regulation (Regulation) of 2-adrenergic in platelets
2) Confidence 0.53 Published 1983 Journal J. Recept. Res. Section Abstract Doc Link 6304294 Disease Relevance 0 Pain Relevance 0.04
The aim of the present study was to investigate beta-adrenergic receptor and angiotensin II (Ang II) receptor modulation of norepinephrine release in human atria.
Spec (investigate) Regulation (modulation) of beta-adrenergic receptor
3) Confidence 0.44 Published 1994 Journal Circ. Res. Section Abstract Doc Link 8118951 Disease Relevance 0 Pain Relevance 0.06
Effects of various catecholamine receptor antagonists, muscle relaxation and physical hindrance on shuttlebox self-stimulation.
Regulation (Effects) of catecholamine receptor in muscle associated with antagonist and catecholamine
4) Confidence 0.43 Published 1982 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 6124008 Disease Relevance 0 Pain Relevance 0.27
These two neuronal cell lines of human origin would prove useful in elucidating the action and regulation of human alpha 2-adrenergic receptors and their interaction with other receptor systems.
Regulation (regulation) of 2-adrenergic in neuronal
5) Confidence 0.39 Published 1989 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2537639 Disease Relevance 0.55 Pain Relevance 0.23
Regulation of human beta 2-adrenergic receptors in lymphocytes (determined by (+/-)-125iodocyanopindolol (ICYP) binding) and alpha 2-adrenergic receptors in platelets (determined by 3H-yohimbine binding) was studied.
Regulation (Regulation) of 2-adrenergic in platelets
6) Confidence 0.39 Published 1983 Journal J. Recept. Res. Section Abstract Doc Link 6304294 Disease Relevance 0 Pain Relevance 0.10
To differentiate beta 1- and beta 2-adrenoceptor-mediated effects in humans, we studied the effects of a 2-wk treatment of 12 male volunteers with the selective beta 1-adrenoceptor antagonist bisoprolol (1 x 10 mg/day) and the beta 2-selective antagonist ICI 118,551 (3 x 25 mg/day) on lymphocyte beta 2-adrenoceptor density and responsiveness [10 microM l-isoproterenol (IPN) evoked adenosine 3',5'-cyclic monophosphate (cAMP) increase] as well as on exercise- and IPN-induced changes in lymphocyte beta 2-adrenoceptor density, blood pressure, heart rate, and plasma norepinephrine levels.
Regulation (changes) of 2-adrenoceptor in lymphocyte associated with adenocard, ipn and antagonist
7) Confidence 0.39 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2830792 Disease Relevance 0 Pain Relevance 0.53
Beta 2-adrenergic receptor and angiotensin II receptor modulation of sympathetic neurotransmission in human atria.
Regulation (modulation) of Beta 2-adrenergic in sympathetic
8) Confidence 0.32 Published 1994 Journal Circ. Res. Section Title Doc Link 8118951 Disease Relevance 0 Pain Relevance 0.10
Because exposure to opiates and cocaine prenatally can alter opioid and catecholamine receptor density and distribution, this in turn could affect the development of neural connections by delaying or accelerating neural outgrowth during fetal and/or postnatal periods (Bardo et al. 1982; Hammer et al. 1989; Spear et al. 1989a, 1989b; Tempel et al. 1988; Tsang and Ng 1980).
Regulation (alter) of catecholamine receptor in neural associated with catecholamine, opiate, opioid and cocaine
9) Confidence 0.27 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8594491 Disease Relevance 0.05 Pain Relevance 0.73
RT-PCR experiments and PDE4 activity measurement were performed in order to assess some of the mechanisms that could be involved in desensitization process and we found that neither ADRB2 and ADRB3 mRNA expression levels nor PDE4 activity were affected by salbutamol or SR 59119A treatments.


Neg (neither) Regulation (affected) of ADRB2
10) Confidence 0.27 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
Chronic opioid regulation of stimulatory beta-2 adrenoceptor (beta-2 AR) signaling was investigated in human mammary epidermoid carcinoma A431 cells stably expressing the cloned rat mu opioid receptor.
Regulation (regulation) of beta-2 AR in A431 associated with squamous cell carcinoma, mu opioid receptor and opioid
11) Confidence 0.24 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996236 Disease Relevance 0.10 Pain Relevance 0.41
Up-regulation of AC in A431/mu 13 cells is characterized by an increased capacity rather than an increased sensitivity of beta-2 AR-stimulated AC.
Regulation (sensitivity) of beta-2 AR-stimulated in A431
12) Confidence 0.24 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996236 Disease Relevance 0.26 Pain Relevance 0.68
The evidence for a change in catecholamine receptor sensitivity was supported compared to the vehicle-treated animals. 5.
Regulation (change) of catecholamine receptor associated with catecholamine
13) Confidence 0.22 Published 1977 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 195762 Disease Relevance 0 Pain Relevance 0.77
Catecholamine receptor agonists: effects on motor activity and rate of tyrosine hydroxylation in mouse brain.
Regulation (effects) of Catecholamine receptor in brain associated with catecholamine and agonist
14) Confidence 0.19 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 181681 Disease Relevance 0.07 Pain Relevance 0.62
These results suggest a role for central alpha 2-adrenergic receptor responsivity in the personality trait characterized by behavioral irritability, but not overt assaultiveness, in humans.
Regulation (role) of 2-adrenergic
15) Confidence 0.17 Published 1991 Journal Psychiatry Res Section Abstract Doc Link 1665918 Disease Relevance 0.26 Pain Relevance 0.20
[Mechanism of the radioprotective effect of catecholamine receptor agonists.
Regulation (effect) of catecholamine receptor associated with catecholamine and agonist
16) Confidence 0.16 Published 1986 Journal Radiobiologiia Section Title Doc Link 2869549 Disease Relevance 0 Pain Relevance 0.31
We further studied the effects of imidapril on blood pressure (BP), in vivo cardiac function, cardiac beta-adrenoceptor distribution, and plasma catecholamine levels after dietary treatment with 480 ppm imidapril for 8-10 weeks from age 37 weeks.
Regulation (effects) of cardiac beta-adrenoceptor in plasma associated with catecholamine
17) Confidence 0.02 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8761854 Disease Relevance 0.45 Pain Relevance 0.13

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