INT124300

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 12.54
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Anatomy Link Frequency
neuronal 2
cardiac muscle 1
liver 1
plaque 1
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 95 96.20 Very High Very High Very High
Angina 8 93.60 High High
Potency 16 86.88 High High
anesthesia 13 77.72 Quite High
ischemia 12 58.56 Quite High
imagery 66 57.16 Quite High
Central nervous system 8 54.72 Quite High
Glutamate 1 52.80 Quite High
Inflammation 45 50.00 Quite Low
cytokine 5 47.04 Quite Low
Disease Link Frequency Relevance Heat
Disease 275 99.84 Very High Very High Very High
Targeted Disruption 297 99.60 Very High Very High Very High
Dilated Cardiomyopathy 23 99.50 Very High Very High Very High
Injury 22 99.08 Very High Very High Very High
Parkinson's Disease 10 98.56 Very High Very High Very High
Stress 369 98.16 Very High Very High Very High
Diabetes Mellitus 71 98.16 Very High Very High Very High
Hyperglycemia 55 97.98 Very High Very High Very High
Aging 94 96.56 Very High Very High Very High
Gestational Diabetes 9 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such aberrant mitochondrial localization was accompanied by decreased mitochondrial manganese superoxide dismutase (Mn-SOD) activity, cytochrome c release into the cytosol, caspase-3 activation, and DNA fragmentation, most predominantly in hippocampal neuronal cells.
Negative_regulation (decreased) of manganese superoxide dismutase in neuronal
1) Confidence 0.45 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644272 Disease Relevance 0.62 Pain Relevance 0.08
During hyperglycemia, excess glucose levels induce over-production of ROS in the mitochondria, which subsequently causes depletion of SOD2 and leads to cellular injury [2], [8]–[10].
Negative_regulation (depletion) of SOD2 associated with hyperglycemia and injury
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.36 Pain Relevance 0.08
To confirm the knockdown of Sod2 gene expression, we examined the in vivo consequence of SOD2 deficiency.
Spec (examined) Negative_regulation (deficiency) of SOD2
3) Confidence 0.43 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.32 Pain Relevance 0
These mice were viable but with phenotypes of SOD2 deficiency.
Negative_regulation (deficiency) of SOD2
4) Confidence 0.43 Published 2006 Journal PLoS Genet Section Abstract Doc Link PMC1358942 Disease Relevance 0.95 Pain Relevance 0
Despite this significant knockdown (by 60%–90%) in all the tissues examined and the evidence of functional SOD2 deficiency, the two transgenic lines were viable to 400 d (observed to date).
Negative_regulation (deficiency) of SOD2 associated with targeted disruption
5) Confidence 0.43 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.89 Pain Relevance 0
Dilated cardiomyopathy develops in mutant mice lacking manganese superoxide dismutase [31] suggesting that the increased oxidative stress may have a role in the pathogenesis of this condition.
Negative_regulation (lacking) of manganese superoxide dismutase associated with stress and dilated cardiomyopathy
6) Confidence 0.42 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119851 Disease Relevance 1.49 Pain Relevance 0
has been shown to enter mitochondria and compromise their integrity through inactivation of the superoxide dismutase 2 (SOD-2) and a subsequent increase in superoxide levels [12].
Negative_regulation (inactivation) of SOD-2
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 1.11 Pain Relevance 0
These transgenics exhibit lower basal levels of liver mitochondrial SOD2 mRNA and protein, lower SOD2 activity levels, reduced lipid oxidation, and increased aconitase activity in mitochondria compared with wild-type mice.
Negative_regulation (exhibit) of SOD2 in liver
8) Confidence 0.38 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.67 Pain Relevance 0
Such aberrant mitochondrial localization was accompanied by decreased mitochondrial manganese superoxide dismutase (Mn-SOD) activity, cytochrome c release into the cytosol, caspase-3 activation, and DNA fragmentation, most predominantly in hippocampal neuronal cells.
Negative_regulation (decreased) of Mn-SOD in neuronal
9) Confidence 0.38 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644272 Disease Relevance 0.62 Pain Relevance 0.08
The deficiency of the Mn-SOD activity was determined using a specific activity assay as described recently [28].
Negative_regulation (deficiency) of Mn-SOD
10) Confidence 0.37 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0 Pain Relevance 0.08
This might be due to the interaction between MnSOD and p53, which leads to inactivation of MnSOD activity, as previous studies have demonstrated [36].
Negative_regulation (inactivation) of MnSOD
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0 Pain Relevance 0.03
Judge et al (2003) postulated that the increase in PC may be a result of the reduction in SOD2 and GPx activity and/or that protein oxidation is transiently elevated in cardiac muscle [38].
Negative_regulation (reduction) of SOD2 in cardiac muscle
12) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.08 Pain Relevance 0
has been shown to enter mitochondria and compromise their integrity through inactivation of the superoxide dismutase 2 (SOD-2) and a subsequent increase in superoxide levels [12].
Negative_regulation (inactivation) of dismutase 2
13) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 1.11 Pain Relevance 0
-induced mitochondrial dysfunction has further been linked to AD through studies showing that the genetic reduction of SOD-2 in AD model mice can amplify multiple AD symptoms [13], [14] and lead to increased plaque deposition [15].
Negative_regulation (reduction) of SOD-2 in plaque associated with parkinson's disease and disease
14) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 1.24 Pain Relevance 0
We here show for the first time data from isometric tension studies indicating that a partial (50 %) deficiency in Mn-SOD and accordingly increased basal mitochondrial ROS levels result in a more pronounced clinical tolerance.
Spec (partial) Negative_regulation (deficiency) of Mn-SOD associated with tolerance
15) Confidence 0.32 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0 Pain Relevance 0.16
Therefore a loss of MnSOD activity during I/R appears to be related to tissue injury.
Negative_regulation (loss) of MnSOD associated with injury
16) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.94 Pain Relevance 0.05
It is worthy of mention that GH administration to dwarf mice, in vivo and in vitro, downregulates the oxidative defense capacity (GPX, catalase, SOD2 [MnSOD]) of these mice (Brown-Borg et al. 2002, Brown-Borg and Rakoczy 2003.
Negative_regulation (downregulates) of SOD2
17) Confidence 0.17 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.31 Pain Relevance 0
The effect on AOE gene expression was strikingly similar in CuZnSOD, MnSOD, and Gpx-1, which were all decreased.
Negative_regulation (decreased) of MnSOD
18) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.61 Pain Relevance 0
We previously reported that the valine allele of MnSOD decreases the mitochondrial MnSOD (mtMnSOD) activity.
Negative_regulation (decreases) of mtMnSOD
19) Confidence 0.11 Published 2010 Journal J Cardiol Section Abstract Doc Link 20206073 Disease Relevance 0.25 Pain Relevance 0.34

General Comments

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