INT124317

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.54
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
HL-60 2
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 99.44 Very High Very High Very High
Morphine 9 98.98 Very High Very High Very High
agonist 2 84.28 Quite High
opioid receptor 1 83.92 Quite High
Opioid 1 77.00 Quite High
Endogenous opioid 1 75.00 Quite High
Inflammation 8 48.20 Quite Low
rheumatoid arthritis 1 18.72 Low Low
Inflammatory response 1 6.96 Low Low
member 8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 10 99.80 Very High Very High Very High
Death 9 99.80 Very High Very High Very High
Lymphatic System Cancer 7 99.30 Very High Very High Very High
Leukemia 3 75.00 Quite High
Asthma 1 69.08 Quite High
Autoimmune Disease 2 68.64 Quite High
INFLAMMATION 9 48.20 Quite Low
Infection 2 25.04 Quite Low
Hypersensitivity 1 22.80 Low Low
Systemic Lupus Erythematosus 1 21.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate molecular events in the apoptosis, protein expressions of Bcl-2, Bax, Fas, and FasL were measured by western blotting using specific antibodies in HL-60 cells.
Regulation (measured) of Gene_expression (expressions) of FasL in HL-60 associated with apoptosis
1) Confidence 0.23 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644942 Disease Relevance 0.67 Pain Relevance 0.24
Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.
Spec (whether) Regulation (regulation) of Gene_expression (expression) of FasL associated with death, cytokine and morphine
2) Confidence 0.20 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.70 Pain Relevance 0.87
The presence of catalytically active Trx1 impeded CD30-dependent signaling in the YT lymphoma cell line, as demonstrated by its effect on CD25 and FasL expression, as well as its influence on cytotoxicity against Fas-expressing target cells.
Regulation (effect) of Gene_expression (expression) of FasL associated with lymphatic system cancer
3) Confidence 0.14 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.17 Pain Relevance 0

General Comments

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