INT124322

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.53
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PNLIP) small molecule metabolic process (PNLIP) extracellular region (PNLIP)
lipid metabolic process (PNLIP)
Anatomy Link Frequency
fat 2
uterine 1
PNLIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 77 96.08 Very High Very High Very High
Inflammation 9 90.88 High High
Cannabinoid receptor 1 86.92 High High
Pain 11 84.92 Quite High
alcohol 6 84.84 Quite High
Analgesic 3 84.60 Quite High
Onset of action 8 83.92 Quite High
Potency 14 77.92 Quite High
agonist 45 77.80 Quite High
Bioavailability 2 76.00 Quite High
Disease Link Frequency Relevance Heat
Pre-term Labor 89 100.00 Very High Very High Very High
Infection 26 100.00 Very High Very High Very High
Chorioamnionitis 6 99.92 Very High Very High Very High
Obesity 111 99.64 Very High Very High Very High
Pancreatitis 70 99.20 Very High Very High Very High
Premature Birth 114 98.44 Very High Very High Very High
Bacterial Vaginosis 15 97.16 Very High Very High Very High
Birth Weight 3 96.48 Very High Very High Very High
Dysmenorrhea 77 96.08 Very High Very High Very High
INFLAMMATION 9 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Although all pancreatic enzyme secretions are simultaneously reduced in severe CP, gastric lipase can compensate partly for the loss of pancreatic lipase but not normalize overall lipolytic activity.


Negative_regulation (loss) of pancreatic lipase
1) Confidence 0.31 Published 2005 Journal Clin. Gastroenterol. Hepatol. Section Body Doc Link 15645402 Disease Relevance 0 Pain Relevance 0
These data demonstrate the safety and efficacy of barusiban in reducing uterine contractility in response to repeated OXT challenge, and suggest that barusiban may be therapeutically effective in long-term treatment of PTL.
Negative_regulation (effective) of PTL in uterine associated with pre-term labor
2) Confidence 0.28 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16914691 Disease Relevance 0.89 Pain Relevance 0.51
OT was intravenously (IV) infused for 3–6 h per day to simulate a situation of PTL with daily periods of spontaneous contractions.
Negative_regulation (situation) of PTL
3) Confidence 0.15 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.05 Pain Relevance 0
Taken together, the presented model is useful for PK/PD evaluation of drug candidates intended to be used in PTL.
Negative_regulation (used) of PTL
4) Confidence 0.15 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.52 Pain Relevance 0.53
Orlistat is a pancreatic lipase inhibitor but should have no effect on pancreatic amylase production.
Negative_regulation (inhibitor) of pancreatic lipase
5) Confidence 0.15 Published 2006 Journal Nutr J Section Body Doc Link PMC1560153 Disease Relevance 0.84 Pain Relevance 0.08
Orlistat is a gastric and pancreatic lipase inhibitor used in obesity management, inhibiting the absorption of fat from the diet and causing a high faecal fat content.
Negative_regulation (inhibitor) of pancreatic lipase in fat associated with obesity
6) Confidence 0.11 Published 2006 Journal Nutr J Section Body Doc Link PMC1560153 Disease Relevance 0.97 Pain Relevance 0.13
In addition, other trials which did not use antibiotics which are active against BV related organisms and anaerobes have not shown any benefit.36–41 A Cochrane systematic review of eleven trials on the use of antibiotics for inhibiting PTL concluded that antibiotic use showed no benefit,42 partly because of small numbers of women included in the trials which used clindamycin or metronidazole compared to trials which did not use them, and mainly the overwhelming weighting of Oracle ?.


Negative_regulation (inhibiting) of PTL associated with bacterial vaginosis
7) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.97 Pain Relevance 0.03
The combination of positive FFN test, and the transvaginal ultrasound scan (TVUSS) of women with a short cervical length (<30 mm) may identify those women who may benefit from interventions such as antibiotics and tocolytics which may reduce PTB.9–11

Infection and PTL

Negative_regulation (reduce) of PTL associated with infection
8) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 1.26 Pain Relevance 0.07
However, OMDM169 shared with tetrahydrolipstatin the capability of inhibiting the human pancreatic lipase (IC(50)=0.6 microM).
Negative_regulation (inhibiting) of pancreatic lipase
9) Confidence 0.09 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19027877 Disease Relevance 0.08 Pain Relevance 0.26
A meta-analysis over a decade ago102 showed that progesterone was beneficial in reducing PTL: odds ratio 0.43 (95% CI 0.20, 0.89); PTB: odds ratio 0.50 (95% CI 0.30, 0.85) and low birth weight (<2500 g): odds ratio 0.50 (95% CI 0.27, 0.80).
Negative_regulation (reducing) of PTL associated with birth weight, premature birth and pre-term labor
10) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 0.67 Pain Relevance 0.12
Orlistat, approved since 1998, is an inhibitor of pancreatic lipase reducing dietary fat absorption.
Negative_regulation (inhibitor) of pancreatic lipase in fat
11) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 0.28 Pain Relevance 0.14

General Comments

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