INT124350

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.79
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gorasp2)
Anatomy Link Frequency
peripheral nerve 1
Gorasp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 6 99.54 Very High Very High Very High
Neuropathic pain 6 98.94 Very High Very High Very High
dexamethasone 2 98.48 Very High Very High Very High
agonist 2 97.92 Very High Very High Very High
nMDA receptor 4 97.14 Very High Very High Very High
antagonist 6 95.00 High High
intrathecal 8 92.96 High High
Inflammation 4 90.12 High High
corticosteroid 2 84.52 Quite High
Spinal cord 2 76.64 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 22 99.54 Very High Very High Very High
Stress 51 99.36 Very High Very High Very High
Neuropathic Pain 6 98.94 Very High Very High Very High
Shock 1 90.40 High High
INFLAMMATION 5 90.12 High High
Stroke 27 88.08 High High
Nociception 2 86.48 High High
Death 2 83.16 Quite High
Injury 1 82.40 Quite High
Targeted Disruption 2 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that interactions between central GRs and NMDARs through genomic and nongenomic regulation may be an important mechanism critical to neuropathic pain behaviors in rats.
GRs Binding (interactions) of associated with neuropathic pain
1) Confidence 0.09 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647493 Disease Relevance 1.06 Pain Relevance 0.73
Central glucocorticoid receptors (GRs) and NMDA receptors (NMDARs) have been shown to play a significant role in the mechanisms of neuropathic pain after peripheral nerve injury; however, how central GRs and NMDARs interact in this process remains unknown.
GRs Binding (interact) of in peripheral nerve associated with nervous system injury, nmda receptor, neuropathic pain and peripheral nerve injury
2) Confidence 0.09 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647493 Disease Relevance 0.66 Pain Relevance 0.46
GRs have low affinity for GCs and become occupied at the time of stress-induced GC elevation.
GRs Binding (occupied) of associated with stress
3) Confidence 0.06 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2954925 Disease Relevance 1.07 Pain Relevance 0.14

General Comments

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