INT124351

Context Info Confidence 0.23 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.70 Pain Relevance 1.38

Golgi apparatus (Gorasp2)

Anatomy Link Frequency BLA 1 Gorasp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat amygdala 9 99.68 agonist 2 94.40 intrathecal 4 94.00 antagonist 4 87.60 Dorsal horn 1 80.60 Spinal cord 1 80.12 Peripheral nerve injury 3 75.00 nMDA receptor 2 75.00 Morphine 3 74.28 Neuropathic pain 3 65.60

Disease Link Frequency Relevance Heat Nervous System Injury 11 99.72 Stress 8 98.38 Targeted Disruption 1 98.20 Nociception 1 84.88 Neuropathic Pain 3 65.60 Drug Dependence 1 38.04 Recurrence 1 32.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results show that stress blocks reconsolidation of a drug-related memory, and this effect is mediated by activation of GRs in the BLA.

Positive_regulation (activation) of GRs in BLA associated with stress and amygdala

1) Confidence 0.23 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18495894 Disease Relevance 0.51 Pain Relevance 0.66

Because IL-6 and PKCgamma mediated the upregulation of central GRs after CCI as demonstrated previously, the results suggest that IL-6 and PKCgamma served as cellular mediators contributing to the GR-mediated expression of NMDARs after CCI.

Positive_regulation (upregulation) of GRs associated with nervous system injury

2) Confidence 0.11 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647493 Disease Relevance 1.18 Pain Relevance 0.73

General Comments

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