INT124351

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.70
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gorasp2)
Anatomy Link Frequency
BLA 1
Gorasp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 9 99.68 Very High Very High Very High
agonist 2 94.40 High High
intrathecal 4 94.00 High High
antagonist 4 87.60 High High
Dorsal horn 1 80.60 Quite High
Spinal cord 1 80.12 Quite High
Peripheral nerve injury 3 75.00 Quite High
nMDA receptor 2 75.00 Quite High
Morphine 3 74.28 Quite High
Neuropathic pain 3 65.60 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 11 99.72 Very High Very High Very High
Stress 8 98.38 Very High Very High Very High
Targeted Disruption 1 98.20 Very High Very High Very High
Nociception 1 84.88 Quite High
Neuropathic Pain 3 65.60 Quite High
Drug Dependence 1 38.04 Quite Low
Recurrence 1 32.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that stress blocks reconsolidation of a drug-related memory, and this effect is mediated by activation of GRs in the BLA.
Positive_regulation (activation) of GRs in BLA associated with stress and amygdala
1) Confidence 0.23 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18495894 Disease Relevance 0.51 Pain Relevance 0.66
Because IL-6 and PKCgamma mediated the upregulation of central GRs after CCI as demonstrated previously, the results suggest that IL-6 and PKCgamma served as cellular mediators contributing to the GR-mediated expression of NMDARs after CCI.
Positive_regulation (upregulation) of GRs associated with nervous system injury
2) Confidence 0.11 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647493 Disease Relevance 1.18 Pain Relevance 0.73

General Comments

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