INT124370

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 47
Total Number 52
Disease Relevance 24.56
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
neuronal 6
livers 4
dentate gyrus 4
embryonic stem cells 4
cerebellum 4
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 3 99.72 Very High Very High Very High
corticosteroid 195 99.40 Very High Very High Very High
long-term potentiation 79 99.12 Very High Very High Very High
Eae 450 98.04 Very High Very High Very High
medulla 39 97.88 Very High Very High Very High
depression 128 97.60 Very High Very High Very High
Kinase C 28 96.48 Very High Very High Very High
agonist 13 95.40 Very High Very High Very High
tolerance 108 93.92 High High
Dopamine 63 92.96 High High
Disease Link Frequency Relevance Heat
Stress 271 99.98 Very High Very High Very High
Toxicity 135 99.90 Very High Very High Very High
Targeted Disruption 1088 99.88 Very High Very High Very High
Aggression 169 99.72 Very High Very High Very High
Drug Induced Neurotoxicity 48 99.52 Very High Very High Very High
Post-traumatic Stress Disorder 78 99.50 Very High Very High Very High
Alagille Syndrome 22 99.22 Very High Very High Very High
Parkinson's Disease 174 98.96 Very High Very High Very High
Manic Depressive Disorder 116 98.80 Very High Very High Very High
Death 214 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IBU-PO (0.01-1 microM) inhibits glycogen-synthase-kinase-3beta (GSK-3beta) and stabilizes cytoplasmic beta-catenin reverting the silencing of the Wnt pathway caused by Abeta-toxicity and GSK-3beta overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GSK-3beta associated with toxicity and abeta
1) Confidence 0.67 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.57 Pain Relevance 0.33
In addition, it has been shown that overexpression of GSK-3?
Positive_regulation (overexpression) of Gene_expression (overexpression) of GSK-3
2) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.96 Pain Relevance 0.42
Changes in psychomotor function and an increased acoustic startle response have been found in mice overexpressing GSK-3?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GSK-3 associated with post-traumatic stress disorder
3) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.70 Pain Relevance 0.42
Transgenic mice overexpressing GSK-3?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GSK-3 associated with targeted disruption
4) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.82 Pain Relevance 0.45
In contrast, mice overexpressing GSK-3?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GSK-3
5) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.32 Pain Relevance 0.03
expression at a level comparable to wild type, while clone 7 had partially (~50% of wild-type) recovered GSK3?
Positive_regulation (recovered) of Gene_expression (recovered) of GSK3
6) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.06 Pain Relevance 0
E14K mouse embryonic stem cells with LoxP-recombination sites flanking exon 2 of GSK3 (both alleles), were made null for GSK3?
Positive_regulation (with) of Gene_expression (embryonic stem cells) of GSK3 in embryonic stem cells
7) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
E14K mouse embryonic stem cells with LoxP-recombination sites flanking exon 2 of GSK3 (both alleles), were made null for GSK3?
Positive_regulation (with) of Gene_expression (made) of GSK3 in embryonic stem cells
8) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
However, re-analysis of these four clones, after only 3 additional passages, revealed that despite retention of puromycin resistance, clone 13 had recovered GSK3?
Positive_regulation (recovered) of Gene_expression (recovered) of GSK3
9) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.11 Pain Relevance 0
could be compensated by the actions of GSK3?
Positive_regulation (compensated) of Gene_expression (actions) of GSK3
10) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.09 Pain Relevance 0
Although numerous attempts at generating stable GSK3?
Positive_regulation (generating) of Gene_expression (generating) of GSK3
11) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.31 Pain Relevance 0
To further study the involvement of GSK-3, transgenic mice that overexpress GSK-3?
Positive_regulation (overexpress) of Gene_expression (overexpress) of GSK-3 associated with targeted disruption
12) Confidence 0.46 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.69 Pain Relevance 0.04
The arbor vita of the cerebellum of the GSK-3?
Positive_regulation (cerebellum) of Gene_expression (cerebellum) of GSK-3 in cerebellum
13) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.48 Pain Relevance 0.22
Immunohistological examination of the cerebellum of GSK-3?
Positive_regulation (cerebellum) of Gene_expression (cerebellum) of GSK-3 in cerebellum
14) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.13 Pain Relevance 0.05
Reduced immobility time has been also shown in mice overexpressing GSK-3?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GSK-3
15) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.46 Pain Relevance 0.40
Moreover, of the distinct behaviors results may be explained in terms of stress responsiveness of the GSK-3?
Positive_regulation (responsiveness) of Gene_expression (responsiveness) of GSK-3 associated with stress
16) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.61 Pain Relevance 0.07
The prepulse inhibition enhancement observed in the GSK-3?
Positive_regulation (observed) of Gene_expression (observed) of GSK-3
17) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.48 Pain Relevance 0.19
On the other hand, no changes in basal and stress-induced corticosteroid levels were detected in mice overexpressing GSK-3?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GSK-3 associated with stress and corticosteroid
18) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.45 Pain Relevance 0.51
During three day trials, relative improvements in rotarod performance were found to be comparable between GSK-3?
Positive_regulation (improvements) of Gene_expression (comparable) of GSK-3
19) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0 Pain Relevance 0.06
(flox/-) stable MEF line, designated as c2.1, was successfully generated in a GSK3?
Positive_regulation (generated) of Gene_expression (generated) of GSK3
20) Confidence 0.41 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.33 Pain Relevance 0

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