INT124372

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2011
Negated 5
Speculated 6
Reported most in Body
Documents 164
Total Number 196
Disease Relevance 95.64
Pain Relevance 14.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
liver 6
neuronal 4
neurons 4
hepatocyte 2
dentate gyrus 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 411 100.00 Very High Very High Very High
Kinase C 183 100.00 Very High Very High Very High
Eae 1118 99.84 Very High Very High Very High
Abeta 3 99.72 Very High Very High Very High
long-term potentiation 168 99.12 Very High Very High Very High
Inflammation 299 98.96 Very High Very High Very High
medulla 81 97.88 Very High Very High Very High
depression 408 97.60 Very High Very High Very High
Dopamine 178 97.20 Very High Very High Very High
tolerance 562 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 3837 100.00 Very High Very High Very High
Aggression 352 100.00 Very High Very High Very High
Insulin Resistance 157 100.00 Very High Very High Very High
Disease 3006 99.98 Very High Very High Very High
Stress 642 99.98 Very High Very High Very High
Sprains And Strains 1106 99.96 Very High Very High Very High
Toxicity 358 99.90 Very High Very High Very High
Prostate Cancer 63 99.86 Very High Very High Very High
Death 675 99.84 Very High Very High Very High
Mantle-cell Lymphoma 33 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IBU-PO (0.01-1 microM) inhibits glycogen-synthase-kinase-3beta (GSK-3beta) and stabilizes cytoplasmic beta-catenin reverting the silencing of the Wnt pathway caused by Abeta-toxicity and GSK-3beta overexpression.
Gene_expression (overexpression) of GSK-3beta associated with toxicity and abeta
1) Confidence 0.75 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.57 Pain Relevance 0.33
However, by TP48, at which A1.4 and A1.6 both have comparable levels of residual GSK3 expression, a delay of ~8 hrs is observed with both clones, with a peak occurring at TP52 (Fig. 3A,B).


Gene_expression (expression) of GSK3
2) Confidence 0.73 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.38 Pain Relevance 0
In parallel with the A1.4 and A1.6 RNA samples, protein extracts were harvested at 0, 4, 24, 36 and 48 hours following the serum shock, in order to monitor the relative reduction in levels of GSK3 expression in the two clones (Fig. 4).
Gene_expression (expression) of GSK3 associated with shock
3) Confidence 0.73 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.47 Pain Relevance 0
In order to further confirm the circadian repercussions of in vitro GSK3 knockdown, and to attribute the observed effects on mPer2 transcriptional cycling specifically to GSK3 expression levels, a genetically defined stable knockout (3/4 DKO) MEF line was generated to circumvent issues of targeting and cellular response specificity presented by the RNAi method of GSK3 knockdown.
Gene_expression (expression) of GSK3 associated with targeted disruption
4) Confidence 0.73 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.24 Pain Relevance 0
As expected, based on the screening process, the A1.6 clone achieved the highest level of "knock-down", especially prior to (TP0) and immediately following (TP4) serum shock, time points at which A1.4 expressed slightly higher levels of GSK3 (Fig. 4).
Gene_expression (expressed) of GSK3 associated with targeted disruption and shock
5) Confidence 0.73 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.44 Pain Relevance 0
In addition, it has been shown that overexpression of GSK-3?
Gene_expression (overexpression) of GSK-3
6) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.96 Pain Relevance 0.42
Reduced immobility time has been also shown in mice overexpressing GSK-3?
Gene_expression (overexpressing) of GSK-3
7) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.46 Pain Relevance 0.40
On the other hand, no changes in basal and stress-induced corticosteroid levels were detected in mice overexpressing GSK-3?
Gene_expression (overexpressing) of GSK-3 associated with stress and corticosteroid
8) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.45 Pain Relevance 0.51
Transgenic mice overexpressing GSK-3?
Gene_expression (overexpressing) of GSK-3 associated with targeted disruption
9) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.82 Pain Relevance 0.45
In contrast, mice overexpressing GSK-3?
Gene_expression (overexpressing) of GSK-3
10) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.32 Pain Relevance 0.03
Changes in psychomotor function and an increased acoustic startle response have been found in mice overexpressing GSK-3?
Gene_expression (overexpressing) of GSK-3 associated with post-traumatic stress disorder
11) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.70 Pain Relevance 0.42
In a setting where the circadian clock mechanism, within a functional range, is relatively insulated from reduction in absolute levels of GSK3, the absence of GSK3?
Neg (absence) Gene_expression (absence) of GSK3
12) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.08 Pain Relevance 0
Lithium lengthens mPer2 period and phenocopies GSK3 knockdown
Gene_expression (knockdown) of GSK3
13) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.35 Pain Relevance 0
Therefore, the targeted "knock down" of the GSK3?
Gene_expression (knock) of GSK3 associated with targeted disruption
14) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.10 Pain Relevance 0
To monitor GSK3 expression in c2.1 relative to A6, protein extracts of both cell lines were harvested at 0, 4, 12, 24, 30 and 36 hours following the serum shock (Fig. 5C) in parallel with the serum shocked A6 and c2.1 RNA samples.
Gene_expression (expression) of GSK3 associated with shock
15) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.41 Pain Relevance 0
with oligos directed against the GSK3?
Gene_expression (directed) of GSK3
16) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
In a setting where the circadian clock mechanism, within a functional range, is relatively insulated from reduction in absolute levels of GSK3, the absence of GSK3?
Gene_expression (levels) of GSK3
17) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.13 Pain Relevance 0
Phase relationship of core clock genes in GSK3?
Gene_expression (genes) of GSK3
18) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.08 Pain Relevance 0
expression at a level comparable to wild type, while clone 7 had partially (~50% of wild-type) recovered GSK3?
Gene_expression (recovered) of GSK3
19) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.06 Pain Relevance 0
Although numerous attempts at generating stable GSK3?
Gene_expression (generating) of GSK3
20) Confidence 0.63 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.31 Pain Relevance 0

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