INT124373

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.28
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
colon 4
smooth muscle cells 2
heart 2
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Abeta 3 100.00 Very High Very High Very High
metalloproteinase 5 96.24 Very High Very High Very High
Potency 6 92.48 High High
cINOD 17 85.00 Quite High
Inflammation 80 84.52 Quite High
Hippocampus 50 79.72 Quite High
Neurotransmitter 3 77.44 Quite High
antagonist 11 68.96 Quite High
Kinase C 26 53.52 Quite High
methotrexate 17 47.24 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 176 100.00 Very High Very High Very High
Toxicity 19 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 3 99.24 Very High Very High Very High
Myocardial Infarction 207 99.20 Very High Very High Very High
Disease 189 98.44 Very High Very High Very High
Cancer 532 96.64 Very High Very High Very High
Apoptosis 375 96.52 Very High Very High Very High
Amyloid Plaque 12 95.84 Very High Very High Very High
Pneumococcal Meningitis 42 94.12 High High
Neurodegenerative Disease 40 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strengthen the hypothesis that an impairment of the Wnt pathway contributes to the pathophysiology of AD [4,5,24,58,59]
Positive_regulation (impairment) of Gene_expression (pathway) of Wnt associated with disease
1) Confidence 0.42 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.85 Pain Relevance 0
result in three hallmarks related with Wnt signaling: (a) destabilization of endogenous levels of ?
Positive_regulation (result) of Gene_expression (related) of Wnt
2) Confidence 0.42 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.73 Pain Relevance 0.05
IBU-PO (0.01-1 microM) inhibits glycogen-synthase-kinase-3beta (GSK-3beta) and stabilizes cytoplasmic beta-catenin reverting the silencing of the Wnt pathway caused by Abeta-toxicity and GSK-3beta overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Wnt associated with toxicity and abeta
3) Confidence 0.21 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.57 Pain Relevance 0.34
The, concomitant tissue- and time-specific activation of both, the wnt-signalling- and the TGF-?
Positive_regulation (activation) of Gene_expression (tissue) of wnt
4) Confidence 0.08 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.38 Pain Relevance 0.04
The, concomitant tissue- and time-specific activation of both, the wnt-signalling- and the TGF-?
Positive_regulation (activation) of Gene_expression (signalling) of wnt
5) Confidence 0.08 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.38 Pain Relevance 0.04
In addition, alterations of canonical Wnt signaling pathway due to frequent mutations in ?
Positive_regulation (alterations) of Gene_expression (alterations) of Wnt
6) Confidence 0.06 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.53 Pain Relevance 0.08
induce Wnt signaling in colon cancer cells through activation of NF-?
Positive_regulation (activation) of Gene_expression (signaling) of Wnt in colon associated with colon cancer
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.86 Pain Relevance 0
-catenin and increases the expression of Wnt target genes [38].
Positive_regulation (increases) of Gene_expression (expression) of Wnt
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.56 Pain Relevance 0
induce Wnt signaling in colon cancer cells through activation of NF-?
Positive_regulation (induce) of Gene_expression (signaling) of Wnt in colon associated with colon cancer
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.85 Pain Relevance 0
-catenin and to promote the expression of Wnt target genes [38].
Positive_regulation (promote) of Gene_expression (expression) of Wnt
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.52 Pain Relevance 0
Moreover, we observed active Wnt signaling in fibroblasts, vWF-positive endothelial cells, vascular smooth muscle cells (?
Positive_regulation (observed) of Gene_expression (observed) of Wnt in smooth muscle cells
11) Confidence 0.03 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.43 Pain Relevance 0
However, this not necessarily means that active Wnt/?
Positive_regulation (active) of Gene_expression (/) of Wnt
12) Confidence 0.03 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.45 Pain Relevance 0.05
Increased number of cells displays active Wnt signaling in the heart after myocardial infarction
Positive_regulation (active) of Gene_expression (signaling) of Wnt in heart associated with myocardial infarction
13) Confidence 0.03 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.10 Pain Relevance 0
Here we show that there indeed might be a close relationship between BMP and Wnt pathways, because at day 1 when BMP4 expression is decreased, expression of TCF4, a Wnt effector, increased significantly, which correlated well with increased proliferation and inhibited epithelial differentiation.
Positive_regulation (increased) of Gene_expression (expression) of Wnt
14) Confidence 0.02 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.05 Pain Relevance 0

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