INT124374

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 10.16
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
neurons 2
smooth muscle cells 1
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 32 99.38 Very High Very High Very High
Abeta 3 99.28 Very High Very High Very High
cINOD 41 97.14 Very High Very High Very High
Inflammation 62 96.90 Very High Very High Very High
fibrosis 221 94.88 High High
Neurotransmitter 2 86.72 High High
Central nervous system 51 84.80 Quite High
Hippocampus 43 81.24 Quite High
adenocard 2 79.16 Quite High
agonist 65 75.20 Quite High
Disease Link Frequency Relevance Heat
Disease 490 99.84 Very High Very High Very High
Drug Induced Neurotoxicity 86 99.56 Very High Very High Very High
Helminth Infection 3 98.16 Very High Very High Very High
Apoptosis 151 98.04 Very High Very High Very High
Neurodegenerative Disease 80 98.04 Very High Very High Very High
Targeted Disruption 62 96.96 Very High Very High Very High
INFLAMMATION 81 96.90 Very High Very High Very High
Myocardial Infarction 69 95.60 Very High Very High Very High
Death 27 95.32 Very High Very High Very High
Cystic Fibrosis 220 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A considerable amount of data has led to a quest to understand the role Wnt signaling may play in AD. ?
Wnt Binding (play) of associated with disease
1) Confidence 0.31 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.79 Pain Relevance 0
-catenin content in hippocampal neurons, suggesting an interaction with the Wnt signaling pathway [109].
Wnt Binding (interaction) of in neurons
2) Confidence 0.31 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.62 Pain Relevance 0.06
Genetic epidemiological data show a link between Wnt signaling and AD.
Wnt Binding (link) of associated with disease
3) Confidence 0.31 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.15 Pain Relevance 0
binds to the Fz CRD at or in close proximity to the Wnt binding site and inhibits ?
Wnt Binding (binding) of
4) Confidence 0.31 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.23 Pain Relevance 0.04
From this it is clear that the integration of these topologically linked pathways represent a true series of biochemical events linking the binding of the Wnt ligand, through activation of Daam1 to the actin polymerization machinery.
Wnt Spec (clear) Binding (binding) of
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929951 Disease Relevance 0.56 Pain Relevance 0
They appear to interact with the Wnt/?
Wnt Binding (interact) of
6) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.02 Pain Relevance 0
Wnt interaction with its receptor results in an increase in the stability of ?
Wnt Binding (interaction) of
7) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.28 Pain Relevance 0.06
The emerging role of Wnt signaling as a therapeutic target for treatment of AD led us to evaluate potential pathways that interact with the Wnt signaling:

(a) Cholinergic dysfunction has been observed in AD patients, indicating its relationship with A?

Wnt Binding (interact) of associated with disease
8) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.76 Pain Relevance 0.13
We report here that a new bifunctional compound IBU-PO, which combines a non-steroidal anti-inflammatory drug (NSAID) (Ibuprofen) and a cholinesterase (ChE) inhibitor (Octyl-Pyridostigmine), is neuroprotective against Abeta-neurotoxicity, and its activity is associated to Wnt signaling components in rat hippocampal and mouse cortical neurons.
Wnt Binding (associated) of in neurons associated with drug induced neurotoxicity, inflammation, cinod and abeta
9) Confidence 0.20 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.59 Pain Relevance 0.36
Upon binding of a member of the wnt family to the corresponding receptor two distinct pathways can be activated.
wnt Binding (binding) of
10) Confidence 0.09 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.50 Pain Relevance 0.04
Thus, indicating a possible link between COX-2 and the Wnt signaling pathway [40].
Wnt Binding (link) of
11) Confidence 0.08 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.39 Pain Relevance 0
The Wnt glycoprotein binds to the transmembrane receptor frizzled and low-density lipoprotein receptor-related protein LRP-5/6 which leads to phosphorlation of LRP by GSK-3 ?
Wnt Binding (binds) of
12) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.36 Pain Relevance 0
However, the influence of Wnt/?
Wnt Binding (influence) of
13) Confidence 0.04 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.44 Pain Relevance 0
In the absence of a Wnt ligand binding to its receptor complex, the cytoplasmic ?
Wnt Binding (binding) of
14) Confidence 0.04 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.82 Pain Relevance 0
Several Wnt ligands have been demonstrated to be expressed in vascular endothelial cells in vitro, including Wnt-7a, Wnt-10b and in vascular smooth muscle cells including Wnt-5a[23].
Wnt Binding (ligands) of in smooth muscle cells
15) Confidence 0.04 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.16 Pain Relevance 0.03
Anti-Dkk1 AntibodyDickoppf1 (DKK1) is a naturally occurring Wnt pathway antagonist which works by preventing the interaction between two key Wnt pathway coreceptors, LRP5/6 and the frizzled Wnt pathway receptor, which results in inhibition of Wnt signal transduction and impaired bone formation [105].
Wnt Binding (interaction) of associated with antagonist
16) Confidence 0.03 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.24 Pain Relevance 0.10
Frizzled or secreted frizzled-related proteins (sFRPs) can compete for Wnt binding, thereby antagonizing Wnt signaling.
Wnt Binding (binding) of
17) Confidence 0.02 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.58 Pain Relevance 0
Very recently, a link between the BMP and the Wnt pathways has been demonstrated.
Wnt Binding (link) of
18) Confidence 0.02 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.07 Pain Relevance 0.03
Anti-Dkk1 AntibodyDickoppf1 (DKK1) is a naturally occurring Wnt pathway antagonist which works by preventing the interaction between two key Wnt pathway coreceptors, LRP5/6 and the frizzled Wnt pathway receptor, which results in inhibition of Wnt signal transduction and impaired bone formation [105].
Wnt Binding (interaction) of associated with antagonist
19) Confidence 0.02 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.24 Pain Relevance 0.10
The interaction between Wnt proteins and cell surface receptors can result in a variety of intracellular responses [1].
Wnt Binding (interaction) of
20) Confidence 0.02 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0 Pain Relevance 0

General Comments

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