INT124375

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 67
Total Number 68
Disease Relevance 38.03
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
macrophages 4
vessels 3
heart 3
brain 2
smooth muscle cells 2
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Abeta 3 100.00 Very High Very High Very High
antagonist 116 99.96 Very High Very High Very High
agonist 90 99.80 Very High Very High Very High
Hippocampus 188 98.88 Very High Very High Very High
metalloproteinase 39 98.68 Very High Very High Very High
tolerance 2 95.04 Very High Very High Very High
Potency 18 92.48 High High
Kinase C 142 91.36 High High
cINOD 91 91.24 High High
Inflammation 276 88.68 High High
Disease Link Frequency Relevance Heat
Cancer 1871 100.00 Very High Very High Very High
Toxicity 116 100.00 Very High Very High Very High
Myeloid Leukemia 126 99.92 Very High Very High Very High
Colon Cancer 402 99.84 Very High Very High Very High
Disease 887 99.54 Very High Very High Very High
Carcinoma 208 99.48 Very High Very High Very High
Non-small-cell Lung Cancer 47 99.24 Very High Very High Very High
Myocardial Infarction 621 99.20 Very High Very High Very High
Metastasis 94 99.16 Very High Very High Very High
Prostate Cancer 45 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dkk-1 negatively modulates the canonical Wnt signaling pathway, thus activating the tau-phosphorylating enzyme GSK-3?
Gene_expression (modulates) of Wnt
1) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.40 Pain Relevance 0.16
These results strengthen the hypothesis that an impairment of the Wnt pathway contributes to the pathophysiology of AD [4,5,24,58,59]
Gene_expression (pathway) of Wnt associated with disease
2) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.85 Pain Relevance 0
They appear to interact with the Wnt/?
Gene_expression (/) of Wnt
3) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.01 Pain Relevance 0
result in three hallmarks related with Wnt signaling: (a) destabilization of endogenous levels of ?
Gene_expression (signaling) of Wnt
4) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.72 Pain Relevance 0.05
The reduction in the Wnt signaling can be due to a gain of function of inhibitors of the Wnt signaling.
Gene_expression (reduction) of Wnt
5) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.23 Pain Relevance 0.27
Cross-talk with other signaling cascades that regulate Wnt/?
Gene_expression (/) of Wnt
6) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Abstract Doc Link PMC2515306 Disease Relevance 0.52 Pain Relevance 0.09
result in three hallmarks related with Wnt signaling: (a) destabilization of endogenous levels of ?
Gene_expression (related) of Wnt
7) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.73 Pain Relevance 0.05
agonists modulate Wnt signaling components, including the inhibition of GSK-3?
Gene_expression (components) of Wnt associated with agonist
8) Confidence 0.56 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.54 Pain Relevance 0.13
Through the analysis of in-situ hybridization of adult mice brains, it was found that numerous Fz receptors and Wnt ligands are expressed across the brain [90].
Gene_expression (expressed) of Wnt in brain
9) Confidence 0.50 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.17 Pain Relevance 0.03
In this context, it is interesting to mention that at least 4 Wnt ligands (Wnts 4, 11, 5a and 7a) present in embryonic hippocampal neurons are also expressed in the adult rat brain [107], indicating that at least some of the Wnt ligands are present throughout the entire lifespan of mammals.
Gene_expression (expressed) of Wnt in brain associated with lifespan
10) Confidence 0.50 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.43 Pain Relevance 0
Expression patterns of Wnt signaling genes correlated with circulating thyroid hormone levels, thyroid histopathology, and the carcinogenic potential of PB and PTU in the rat.
Gene_expression (Expression) of Wnt in thyroid
11) Confidence 0.42 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.21 Pain Relevance 0
Differential transcript profiles, possibly relevant to rodent follicular cell tumor outcomes, were observed in rats exposed to PB and PTU, including genes involved in Wnt signaling and ribosomal protein expression.



Gene_expression (expression) of Wnt associated with cancer
12) Confidence 0.37 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1281279 Disease Relevance 0.37 Pain Relevance 0
PTU also altered the expression of other Wnt target genes, including multiple cyclin D3 (Ccnd3) transcripts and urokinase plasminogen activator receptor (Plau) mRNA (Table 6, Figure 3).
Gene_expression (expression) of Wnt
13) Confidence 0.33 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.23 Pain Relevance 0.12
Recently, it has been reported that the Wnt/?
Gene_expression (/) of Wnt
14) Confidence 0.29 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
IBU-PO (0.01-1 microM) inhibits glycogen-synthase-kinase-3beta (GSK-3beta) and stabilizes cytoplasmic beta-catenin reverting the silencing of the Wnt pathway caused by Abeta-toxicity and GSK-3beta overexpression.
Gene_expression (overexpression) of Wnt associated with toxicity and abeta
15) Confidence 0.28 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.57 Pain Relevance 0.34
In contrast to wild-type mice, Wnt/?
Gene_expression (/) of Wnt
16) Confidence 0.15 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.59 Pain Relevance 0
The Wnt family of glycoproteins are involved in activation of the Wnt /  ?
Gene_expression (family) of Wnt
17) Confidence 0.14 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.49 Pain Relevance 0
The Wnt pathway involves a large network of proteins that can regulate the production of Wnt signaling molecules [2].
Gene_expression (production) of Wnt
18) Confidence 0.13 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0 Pain Relevance 0
[68] by inhibition of the TCF/LEF transcription factor [69] and by enhancing the expression of Wnt inhibitors [70-72].
Gene_expression (expression) of Wnt
19) Confidence 0.12 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.60 Pain Relevance 0.26
, while VPA interacts with the Wnt pathway by increasing ?
Gene_expression (pathway) of Wnt
20) Confidence 0.12 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.29 Pain Relevance 0.31

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