INT124389

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.14
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRK6)
Anatomy Link Frequency
melanocytes 2
GRK6 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 22 99.18 Very High Very High Very High
agonist 11 97.60 Very High Very High Very High
Kinase C 2 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Skin Cancer 14 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both melanoma cells and normal melanocytes express two members of the G protein-coupled receptor kinase (GRK) family, GRK2 and GRK6.
Gene_expression (express) of GRK6 in melanocytes associated with skin cancer
1) Confidence 0.70 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15650023 Disease Relevance 0.42 Pain Relevance 0.74
Cotransfection of the receptor and GRK2 or GRK6 genes in heterologous cells demonstrated that GRK2 and GRK6 impair agonist-dependent signaling by MC1R or Mc1r.
Gene_expression (Cotransfection) of GRK6 associated with melanocortin 1 receptor and agonist
2) Confidence 0.70 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15650023 Disease Relevance 0.41 Pain Relevance 0.75
We have shown that MC1R desensitization is mediated by two GRKs expressed in melanocytes and melanoma cells, GRK2 and GRK6.
Gene_expression (expressed) of GRK6 in melanocytes associated with melanocortin 1 receptor and skin cancer
3) Confidence 0.61 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17130136 Disease Relevance 0.31 Pain Relevance 0.68

General Comments

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