INT12440

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 15
Disease Relevance 3.20
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
neurons 3
plasma 1
spinal cord 1
brain 1
dorsal horn 1
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 56 99.96 Very High Very High Very High
agonist 51 99.96 Very High Very High Very High
Desipramine 6 99.90 Very High Very High Very High
gABA 50 99.52 Very High Very High Very High
Calcium channel 15 99.48 Very High Very High Very High
Antinociceptive 2 99.42 Very High Very High Very High
Spinal cord 56 99.28 Very High Very High Very High
tetrodotoxin 16 98.64 Very High Very High Very High
Analgesic 2 98.62 Very High Very High Very High
Inflammation 2 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 22 99.84 Very High Very High Very High
INFLAMMATION 2 98.12 Very High Very High Very High
Fever 2 97.68 Very High Very High Very High
Nociception 3 96.80 Very High Very High Very High
Pain 6 95.28 Very High Very High Very High
Neuropathic Pain 1 93.16 High High
Hypoxia 2 92.88 High High
Anxiety Disorder 1 91.52 High High
Cognitive Disorder 2 91.16 High High
Hypothermia 3 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord.
Regulation (changes) of GABAB in dorsal horn associated with desipramine, analgesic, dorsal horn, antinociceptive and spinal cord
1) Confidence 0.45 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 14757174 Disease Relevance 0.23 Pain Relevance 0.93
We conclude that GABA release onto TM neurons is under presynaptic control via GABAB receptors.
Regulation (control) of GABAB in neurons associated with gaba
2) Confidence 0.44 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10103111 Disease Relevance 0 Pain Relevance 0.35
Furthermore the intriguing possibility of GABAB receptors with specific sensitivities to baclofen prompted us to determine how very low concentrations of baclofen affects both pre- and postsynaptic GABAB receptors on SPNs in the thoracic spinal cord slice preparation.


Regulation (affects) of GABAB in spinal cord associated with spinal cord
3) Confidence 0.32 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.06 Pain Relevance 0.15
However, to date, there is a lack of information regarding the effect of GABAB receptor activation on the release of somatodendritic dopamine from the isolated VTA.
Regulation (effect) of GABAB associated with ventral tegmentum and dopamine
4) Confidence 0.28 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.69
However, the mechanisms that regulate GABAB receptor oligomerization at the plasma membrane remain largely unknown.
Regulation (regulate) of GABAB in plasma
5) Confidence 0.27 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17425567 Disease Relevance 0 Pain Relevance 0.33
The present study investigates the effects of GABAA- and GABAB-receptor agonists and antagonists on gastric secretion after their i.c.v. administration to conscious pylorus-ligated rats and anaesthetized stomach lumen-perfused rats.
Spec (investigates) Regulation (effects) of GABAB-receptor in lumen associated with antagonist and agonist
6) Confidence 0.24 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2155808 Disease Relevance 0 Pain Relevance 0.10
The lack of data regarding a role for GABAB autoreceptors in spinal cord circuitry underlying sympathetic control led us to examine how GABAB receptors may affect synaptic inhibitory transmission from both descending and local inputs onto SPNs.
Regulation (role) of GABAB in sympathetic associated with spinal cord
7) Confidence 0.23 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.12
There are developmental changes in GABAB receptor subunits since GABAB1(a) is predominant during embryonic period and at birth whilst GABAB1(b) expression increases during the first postnatal month in the brain (Fritschy et al., 1994).
Regulation (changes) of GABAB receptor in brain
8) Confidence 0.23 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.10
Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons.
Regulation (modulation) of GABAB in suprachiasmatic nucleus associated with gaba and calcium channel
9) Confidence 0.17 Published 1998 Journal J. Neurosci. Section Title Doc Link 9465016 Disease Relevance 0.06 Pain Relevance 0.41
GABAB1R agonists promote and antagonists inhibit convulsive activity in these models and GABAB1R appear to be functionally up regulated in epileptic mice [18-21].
Regulation (regulated) of GABAB1R associated with epilepsy, antagonist and agonist
10) Confidence 0.15 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 1.58 Pain Relevance 0.45
The effect of THA on presynaptic GABAB receptor-mediated responses was studied in neurons perfused internally with Cs+ and lidocaine N-ethyl bromide (QX-314), which blocked post-synaptic GABAB receptor-mediated responses.
Regulation (responses) of GABAB in neurons associated with lidocaine
11) Confidence 0.14 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8096243 Disease Relevance 0.24 Pain Relevance 0.44
The effect of THA on postsynaptic GABAB receptor-mediated responses was studied in neurons perfused internally with potassium gluconate and guanosine triphosphate (GTP).
Regulation (responses) of GABAB in neurons
12) Confidence 0.14 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8096243 Disease Relevance 0 Pain Relevance 0.20
This electrophysiological study examined the effects of the GABAA and GABAB receptor antagonists, bicuculline and CGP35348, on the magnitude and duration of the formalin response.
Spec (examined) Regulation (effects) of GABAB receptor associated with antagonist
13) Confidence 0.13 Published 1997 Journal Eur J Pain Section Abstract Doc Link 15102410 Disease Relevance 0.38 Pain Relevance 0.52
In contrast, these vessels were unresponsive to the GABAB receptor antagonist, 2-hydroxysaclofen.
Regulation (unresponsive) of GABAB receptor in vessels associated with antagonist
14) Confidence 0.12 Published 1997 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 9307613 Disease Relevance 0.32 Pain Relevance 0.62
It can be concluded that GABA may be involved in the control of BT through GABAA and GABAB receptors.
Regulation (control) of GABAB associated with gaba
15) Confidence 0.08 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1647343 Disease Relevance 0.32 Pain Relevance 0.67

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox