INT124407

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 5.55
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SSTR1) cell-cell signaling (SSTR1) signal transducer activity (SSTR1)
Anatomy Link Frequency
vessels 1
SSTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 442 100.00 Very High Very High Very High
Dopamine 20 93.96 High High
methotrexate 1 93.28 High High
imagery 38 85.12 High High
Central nervous system 1 66.96 Quite High
Pain 1 51.44 Quite High
headache 5 24.36 Low Low
agonist 12 12.08 Low Low
Serotonin 22 5.00 Very Low Very Low Very Low
Potency 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoid 106 99.52 Very High Very High Very High
Cancer 395 99.40 Very High Very High Very High
Glucagonoma 24 99.06 Very High Very High Very High
Neuroendocrine Cancer 66 95.52 Very High Very High Very High
Pancreatic Cancer 16 92.24 High High
Metastasis 91 91.12 High High
Malignant Neoplastic Disease 24 89.60 High High
Insulinoma 48 84.00 Quite High
Disease 100 83.88 Quite High
Hypoglycemia 20 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An antiproliferative effect was achieved on hepatic metastatic cells in a patient with a carcinoid tumour, selected for the treatment with SST analogues after the immunohistochemical identification of the SSTR 1, 2 and 5 subtypes expression on the neoplastic cell surface [86].
Gene_expression (expression) of SSTR 1 associated with carcinoid and somatostatin
1) Confidence 0.55 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.06 Pain Relevance 0.09
It has been reported that in glucagonoma patients there are no data available on their SSTR expression patterns [45].
Gene_expression (expression) of SSTR associated with glucagonoma
2) Confidence 0.48 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.88 Pain Relevance 0.14
In a study examining 81 functioning and non-functioning GEP NETs the large parte of the tumours expressed SSTRs 1, 2, 3 and 5, while SSTR 4 was detected only in a small minority [10].
Gene_expression (detected) of SSTR associated with cancer
3) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.97 Pain Relevance 0.24
Primary tumour growth and angiogenesis were highly decreased and associated with a reduction in microvessel density, inhibition of intratumoural production of VEGF and up-regulation of antiangiogenic SSTR 3 receptor expression in peripheral tumour vessels [32,113,114].


Gene_expression (expression) of SSTR in vessels associated with cancer
4) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.84 Pain Relevance 0.18
A promising approach is the concept of somatostatin receptor (SSTR)-mediated chemo-or radiotherapy of SSTR-expressing metastatic carcinoid.
Gene_expression (expressing) of somatostatin receptor associated with carcinoid and somatostatin
5) Confidence 0.35 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1524962 Disease Relevance 0.56 Pain Relevance 0.17
The in vivo stability of this dextran-conjugated derivative, somatostatin-D70, was confirmed previously in animal studies, and the nanomolar "panaffinity" has been shown in in vitro receptor binding studies on cell lines transfected with the somatostatin receptor genes.
Gene_expression (transfected) of somatostatin receptor associated with somatostatin
6) Confidence 0.01 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15650261 Disease Relevance 0.60 Pain Relevance 0.44
Additionally an expression of somatostatin receptor was detected.

3.

Gene_expression (expression) of somatostatin receptor associated with somatostatin
7) Confidence 0.01 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2330022 Disease Relevance 0.64 Pain Relevance 0.15

General Comments

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