INT12441

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 29
Total Number 38
Disease Relevance 5.70
Pain Relevance 24.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
spinal cord 2
brain 2
hypothalamus 2
neurons 2
nucleus 1
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 30 100.00 Very High Very High Very High
mu opioid receptor 5 100.00 Very High Very High Very High
Desipramine 12 99.98 Very High Very High Very High
antagonist 163 99.96 Very High Very High Very High
GABAergic 201 99.84 Very High Very High Very High
Gabapentin 108 99.84 Very High Very High Very High
Calcitonin gene-related peptide 64 99.84 Very High Very High Very High
tetrodotoxin 129 99.76 Very High Very High Very High
depression 14 99.60 Very High Very High Very High
substance P 65 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 14 99.60 Very High Very High Very High
Hypothermia 4 98.80 Very High Very High Very High
Pain 71 98.76 Very High Very High Very High
Aids-related Complex 10 97.48 Very High Very High Very High
Nociception 73 97.40 Very High Very High Very High
Heart Rate Under Development 4 93.20 High High
Urological Neuroanatomy 131 92.72 High High
Stress 30 92.72 High High
Fever 4 92.40 High High
Bordatella Infection 15 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have utilized electrophysiological methods in an in vitro brain slice preparation to examine the role of GABAB receptor activation in GABAergic synaptic inhibition in histaminergic neurons of the tuberomammillary nucleus.
Spec (examine) Positive_regulation (activation) of GABAB in brain associated with gabaergic
1) Confidence 0.67 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10103111 Disease Relevance 0 Pain Relevance 0.33
The activation of GABAB receptors did not modulate postsynaptic GABAA receptor responses.
Positive_regulation (activation) of GABAB
2) Confidence 0.50 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9465016 Disease Relevance 0.15 Pain Relevance 0.59
We conclude that GABAB receptor activation exerts a strong presynaptic inhibition of GABA release in SCN neurons, primarily by modulating P/Q-type calcium channels at axon terminals.
Positive_regulation (activation) of GABAB receptor in SCN associated with gaba and calcium channel
3) Confidence 0.50 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9465016 Disease Relevance 0.16 Pain Relevance 0.57
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Positive_regulation (enhances) of GABAB associated with desipramine
4) Confidence 0.50 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.23 Pain Relevance 1.02
For the study, rats were injected (i.p.) once daily with desipramine (15 mg/kg) for 7 consecutive days, during which their thermal withdrawal threshold was monitored, and after which GABAB receptor function, and the levels of GABAB receptor subunit mRNA, were quantified in the spinal cord dorsal horn.
Positive_regulation (levels) of GABAB in spinal cord dorsal horn associated with desipramine, dorsal horn, withdrawal and spinal cord
5) Confidence 0.50 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.24 Pain Relevance 0.96
Activation of GABAB receptors has been reported to inhibit the spontaneous pacemaker-like activity of VTA DA neurones in slice preparations [4,28,29] and to decrease the firing rate and burst firing of these cells in vivo [30,31].
Positive_regulation (Activation) of GABAB associated with ventral tegmentum and dopamine
6) Confidence 0.43 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.05
Interestingly, previous neurochemical studies have shown that activation of GABAB receptors in the ventral tegmental area of naïve rats inhibits the release of dopamine not only in the cell body area, but also in mesocorticolimbic terminal regions, such as the nucleus accumbens [33] and the prefrontal cortex [15].
Positive_regulation (activation) of GABAB in cortex associated with nucleus accumbens, ventral tegmentum and dopamine
7) Confidence 0.43 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.80
This effect appears to be mediated by activation of GABAB receptors, since it was abolished by superfusion of the tissue with the selective receptor antagonist CGP55845A [48].
Positive_regulation (activation) of GABAB associated with antagonist
8) Confidence 0.43 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.77
The results show that activation of GABAB receptors decreased GABAA receptor-mediated synaptic input to cerebellar Purkinje cells both by lowering the firing rate of the inhibitory input neurons and by inhibiting GABA release from their axon terminals with a presynaptic mechanism.
Positive_regulation (activation) of GABAB in Purkinje cells associated with gaba
9) Confidence 0.42 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12059965 Disease Relevance 0.06 Pain Relevance 0.39
This study provides evidence that activation of GABAB autoreceptors suppresses GABAergic inhibitory transmission.
Positive_regulation (activation) of GABAB associated with gabaergic
10) Confidence 0.36 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.14 Pain Relevance 0.13
This is likely due to the efficient uptake systems in place to remove GABA since uptake inhibitors increase the likelihood of activation of the GABAB receptors (Isaacson et al., 1993; Scanziani, 2000).
Positive_regulation (activation) of GABAB associated with gaba
11) Confidence 0.36 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.13 Pain Relevance 0.36
Therefore, any membrane potential changes due to opening of K+ channels associated with activation of GABAB receptors should no longer be seen.
Positive_regulation (activation) of GABAB
12) Confidence 0.36 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0
This study examined the effects of selective activation of GABAB and/or mu-opioid receptors on neurons of the arcuate nucelus (ARC) of the rat hypothalamus using intracellular recording of cells in a hypothalamic slice.
Spec (examined) Positive_regulation (activation) of GABAB in hypothalamus associated with aids-related complex and mu opioid receptor
13) Confidence 0.34 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1664497 Disease Relevance 0.23 Pain Relevance 0.36
GH response to acute GABAB receptor activation did not differ between depressed subjects and healthy controls.
Positive_regulation (activation) of GABAB receptor
14) Confidence 0.33 Published 1990 Journal J Affect Disord Section Abstract Doc Link 2174069 Disease Relevance 0.23 Pain Relevance 0.58
The absence of tonic GABAB activation on SPNs has also been reported using a splanchnic nerve–spinal cord preparation (Cheng et al., 2005).


Positive_regulation (activation) of GABAB in spinal cord associated with spinal cord
15) Confidence 0.31 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.12 Pain Relevance 0.35
However, to date, there is a lack of information regarding the effect of GABAB receptor activation on the release of somatodendritic dopamine from the isolated VTA.
Positive_regulation (activation) of GABAB associated with ventral tegmentum and dopamine
16) Confidence 0.29 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.71
Our results demonstrate that GABAB receptor activation reduces the release of DA from the rat VTA.
Positive_regulation (activation) of GABAB associated with ventral tegmentum
17) Confidence 0.29 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.88
The activation of GABAB receptors has also been reported to inhibit the potassium- or electrically evoked release of dopamine from various regions of the mammalian brain in vitro [46,47].
Positive_regulation (activation) of GABAB in brain associated with dopamine
18) Confidence 0.29 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.69
In conclusion, we have demonstrated that activation of GABAB receptors inhibits the release of preloaded [3H]-DA from somatodendritic fields of VTA neurones in naïve rats.
Positive_regulation (activation) of GABAB associated with ventral tegmentum and dopamine
19) Confidence 0.29 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.61
The activation of GABAB receptors in the ventral tegmental area (VTA) has been suggested to attenuate the rewarding properties of psychostimulants, including nicotine.
Positive_regulation (activation) of GABAB in ventral associated with ventral tegmentum and nicotine
20) Confidence 0.29 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.47

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