INT124417

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 8.65
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B12 1
heart 1
Mthfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Restless leg syndrome 44 93.80 High High
Chronic pancreatitis 6 93.68 High High
headache 6 92.80 High High
Pain 8 92.00 High High
Migraine 18 90.96 High High
cva 4 69.60 Quite High
Inflammation 20 54.64 Quite High
Piles 12 25.36 Quite Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 240 99.80 Very High Very High Very High
Coronary Heart Disease 1 98.88 Very High Very High Very High
Atherosclerosis 84 97.76 Very High Very High Very High
Disease 65 96.96 Very High Very High Very High
Pancreatitis 6 93.68 High High
Coronary Artery Disease 17 92.96 High High
Headache 11 92.80 High High
Pain 12 92.00 High High
Nicotine Addiction 45 91.68 High High
Adenocarcinoma 6 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One such candidate is the gene encoding methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the alternative pathway of homocysteine metabolism that remethylates homocysteine to methionine.
Gene_expression (encoding) of MTHFR
1) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 1.48 Pain Relevance 0.13
In spite of the small sample size, the observation of an OR of greater than 3.5 for the MTHFR genotype and PAD suggests an association of notably strong magnitude which would be of interest to confirm in future studies.
Gene_expression (genotype) of MTHFR associated with peripheral arterial disease
2) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 0.99 Pain Relevance 0.07
One such candidate is the gene encoding methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the alternative pathway of homocysteine metabolism that remethylates homocysteine to methionine.
Gene_expression (encoding) of methylenetetrahydrofolate reductase
3) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 1.47 Pain Relevance 0.13
Although, no statistically significant differences were observed in the distribution of MTHFR genotype or allele frequencies between patients and control groups, the results showed an increased frequency of homozygotes for MTHFR C677T polymorphism in chronic pancreatitis patients (14%) and a decreased frequency in pancreatic adenocarcinoma patients (5%) in comparison to the control group (8%).
Gene_expression (distribution) of MTHFR associated with adenocarcinoma and chronic pancreatitis
4) Confidence 0.60 Published 2008 Journal Cell Biochem. Funct. Section Abstract Doc Link 18636416 Disease Relevance 1.04 Pain Relevance 0.47
Genotyping MTHFR 677C>T
Gene_expression (677C>T) of MTHFR
5) Confidence 0.52 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 0.86 Pain Relevance 0.36
In this remethylation pathway, cobalamin (vitamin B12) is involved as an intermediate carrier of the methyl group while the 5-methylTHF is synthesized by MTHFR.
Gene_expression (synthesized) of MTHFR in B12
6) Confidence 0.48 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.30 Pain Relevance 0
The genotype distributions of MTHFR, MTRR and TCN polymorphisms did not differ between controls and UC patients (table 2).
Gene_expression (polymorphisms) of MTHFR
7) Confidence 0.42 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.13 Pain Relevance 0.03
The genotype distributions of MTHFR, MTRR and TCN polymorphisms did not differ between controls and UC patients (table 2).
Gene_expression (distributions) of MTHFR
8) Confidence 0.42 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.13 Pain Relevance 0.03
In contrast, both 677TT and 1298AC/677CT genotypes are known to produce a decreased catalytic enzyme activity of MTHFR [2].
Gene_expression (produce) of MTHFR
9) Confidence 0.38 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.44 Pain Relevance 0.03
The homozygous 677 C>T mutation in the MTHFR gene was present in 20 % of patients.
Gene_expression (present) of MTHFR
10) Confidence 0.30 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1145135 Disease Relevance 0.09 Pain Relevance 0
The C677T allelic variation of 5,10-methylenetetrahydrofolate reductase (MTHFR) are focused on in association with the coronary heart diseases and the cerebrovascular diseases.
Gene_expression (focused) of MTHFR in heart associated with disease and coronary heart disease
11) Confidence 0.08 Published 2004 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15651339 Disease Relevance 1.54 Pain Relevance 1.26

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