INT124418

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.52
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Mthfr)
Anatomy Link Frequency
heart 1
Mthfr (Mus musculus)
Mthfr - C677T (1)
Pain Link Frequency Relevance Heat
headache 6 94.48 High High
Migraine 18 91.88 High High
methotrexate 70 89.44 High High
Arthritis 29 85.68 High High
adenocard 10 39.68 Quite Low
Inflammation 12 27.84 Quite Low
chemokine 14 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 1 98.88 Very High Very High Very High
Diabetes Mellitus 308 97.40 Very High Very High Very High
Renal Disease 10 97.20 Very High Very High Very High
Disease 28 96.96 Very High Very High Very High
Toxicity 22 95.32 Very High Very High Very High
Headache 11 94.48 High High
Migraine With Aura 7 92.28 High High
Juvenile Chronic Polyarthritis 23 85.68 High High
Autoimmune Disease 30 82.40 Quite High
Epilepsy 1 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Certain polymorphisms in the MTHFR gene have been associated with greater clinical improvement (MTHFR 1298AA and MTHFR 677CC genotypes) while MTHFR 1298C and MTHFR 677T alleles have been associated with an increased risk for toxicity [43, 46, 47].
Gene_expression (1298AA) of MTHFR associated with toxicity
1) Confidence 0.60 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.59 Pain Relevance 0.25
The C677T Mthfr (5,10-methylenetetrahydrofolate reductase) polymorphism does not have a significant role in the development of diabetic nephropathy in T1D [45, 46], although this gene was reported in type 2 diabetes development [47].
Gene_expression (reductase) of Mthfr (C677T) associated with diabetes mellitus and renal disease
2) Confidence 0.47 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.19 Pain Relevance 0
The C677T Mthfr (5,10-methylenetetrahydrofolate reductase) polymorphism does not have a significant role in the development of diabetic nephropathy in T1D [45, 46], although this gene was reported in type 2 diabetes development [47].
Gene_expression (reductase) of 5,10-methylenetetrahydrofolate associated with diabetes mellitus and renal disease
3) Confidence 0.47 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.18 Pain Relevance 0
The C677T allelic variation of 5,10-methylenetetrahydrofolate reductase (MTHFR) are focused on in association with the coronary heart diseases and the cerebrovascular diseases.
Gene_expression (focused) of 5,10-methylenetetrahydrofolate reductase in heart associated with disease and coronary heart disease
4) Confidence 0.07 Published 2004 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15651339 Disease Relevance 1.56 Pain Relevance 1.29

General Comments

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