INT12442

Context Info Confidence 0.73 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 4.85 Pain Relevance 1.68

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa) extracellular region (Vegfa) cytoplasm (Vegfa)

Anatomy Link Frequency blood 1 neuronal 1 liver 1 nerve 1 duodenum 1 Vegfa (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nerve growth factor 6 99.44 Pain 5 99.20 ischemia 17 99.08 agonist 2 92.36 Calcium channel 1 89.40 Spinal cord 100 88.56 Bile 53 87.60 lidocaine 8 86.48 imagery 62 76.40 cytokine 24 73.12

Disease Link Frequency Relevance Heat Glioma 117 99.86 Cancer 257 99.84 Cv Unclassified Under Development 15 99.08 Metastasis 1 99.00 Apoptosis 16 98.72 Solid Tumor 25 98.62 Malignant Neoplastic Disease 45 98.38 Hypoxia 43 97.84 Cholestasis 33 94.28 Neurodegenerative Disease 7 94.08

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, EGF, trefoil peptide (pS2/TFF1), platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) were measured.

Localization (measured) of vascular endothelial growth factor in platelet

1) Confidence 0.73 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.29 Pain Relevance 0

Morphologic and ultrastructural changes associated with ischemia including hypervascularization and increased vascular endothelial growth factor release were identified in painful patellofemoral malalignment.

Localization (release) of vascular endothelial growth factor associated with pain and ischemia

2) Confidence 0.70 Published 2005 Journal Orthopedics Section Abstract Doc Link 16138473 Disease Relevance 0.35 Pain Relevance 0.39

SON angiogenesis is related to neuronal vascular endothelial growth factor

Localization (related) of vascular endothelial growth factor in neuronal

3) Confidence 0.52 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0 Pain Relevance 0

The modulation exerted by the endothelium on alpha 1- and alpha 2-adrenergic-induced contractions in rat aortic rings seems to depend both on extracellular Ca2+ concentration and on the release and action of endothelial relaxing factor(s).

Localization (release) of endothelial relaxing factor in endothelium

4) Confidence 0.51 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1647347 Disease Relevance 0 Pain Relevance 0.16

This hyper-permeability of malignant solid tumor microvasculature to macromolecules has been attributed to the local release of vascular permeability factor in tumor tissue[3,4].

Localization (release) of vascular permeability factor associated with malignant neoplastic disease, cancer and solid tumor

5) Confidence 0.34 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.72 Pain Relevance 0

Malignant glioma cells release vascular endothelial growth factor (VEGF), an important regulator and promoter of angiogenesis [4].

Localization (release) of vascular endothelial growth factor associated with glioma

6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 0.96 Pain Relevance 0.11

They also secrete trophic factors such as vascular endothelial growth factor (VEGF) [54], nerve growth factor (NGF), and BDNF [55].

Localization (secrete) of vascular endothelial growth factor in nerve associated with nerve growth factor

7) Confidence 0.22 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.16 Pain Relevance 0.16

The liver suffers increased cholangiocyte apoptosis, impaired cholangiocyte proliferation, decreased cholangiocyte vascular endothelial growth factor (VEGF) secretion and the disappearance of the peribiliary plexus.

Localization (secretion) of vascular endothelial growth factor in liver associated with apoptosis

8) Confidence 0.18 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.19 Pain Relevance 0.12

Vascular endothelial growth factor (VEGF) is an angiogenic factor released by cells in response to certain stressors, including hypoxia.

Localization (released) of Vascular endothelial growth factor associated with hypoxia

9) Confidence 0.17 Published 2010 Journal J Mol Neurosci Section Body Doc Link PMC2825316 Disease Relevance 0.78 Pain Relevance 0.03

Mechanistically it appears that cord blood CD34 cells mediate effects in part through secretion of glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF) [95].

Localization (secretion) of vascular endothelial growth factor in blood

10) Confidence 0.15 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2989319 Disease Relevance 0.39 Pain Relevance 0.14

COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum.

Localization (secretion) of permeability in duodenum

11) Confidence 0.03 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11668025 Disease Relevance 0 Pain Relevance 0.56

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