INT12442

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Context Info
Confidence 0.73
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.85
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
blood 1
neuronal 1
liver 1
nerve 1
duodenum 1
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 6 99.44 Very High Very High Very High
Pain 5 99.20 Very High Very High Very High
ischemia 17 99.08 Very High Very High Very High
agonist 2 92.36 High High
Calcium channel 1 89.40 High High
Spinal cord 100 88.56 High High
Bile 53 87.60 High High
lidocaine 8 86.48 High High
imagery 62 76.40 Quite High
cytokine 24 73.12 Quite High
Disease Link Frequency Relevance Heat
Glioma 117 99.86 Very High Very High Very High
Cancer 257 99.84 Very High Very High Very High
Cv Unclassified Under Development 15 99.08 Very High Very High Very High
Metastasis 1 99.00 Very High Very High Very High
Apoptosis 16 98.72 Very High Very High Very High
Solid Tumor 25 98.62 Very High Very High Very High
Malignant Neoplastic Disease 45 98.38 Very High Very High Very High
Hypoxia 43 97.84 Very High Very High Very High
Cholestasis 33 94.28 High High
Neurodegenerative Disease 7 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, EGF, trefoil peptide (pS2/TFF1), platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) were measured.


Localization (measured) of vascular endothelial growth factor in platelet
1) Confidence 0.73 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.29 Pain Relevance 0
Morphologic and ultrastructural changes associated with ischemia including hypervascularization and increased vascular endothelial growth factor release were identified in painful patellofemoral malalignment.
Localization (release) of vascular endothelial growth factor associated with pain and ischemia
2) Confidence 0.70 Published 2005 Journal Orthopedics Section Abstract Doc Link 16138473 Disease Relevance 0.35 Pain Relevance 0.39
SON angiogenesis is related to neuronal vascular endothelial growth factor
Localization (related) of vascular endothelial growth factor in neuronal
3) Confidence 0.52 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0 Pain Relevance 0
The modulation exerted by the endothelium on alpha 1- and alpha 2-adrenergic-induced contractions in rat aortic rings seems to depend both on extracellular Ca2+ concentration and on the release and action of endothelial relaxing factor(s).
Localization (release) of endothelial relaxing factor in endothelium
4) Confidence 0.51 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1647347 Disease Relevance 0 Pain Relevance 0.16
This hyper-permeability of malignant solid tumor microvasculature to macromolecules has been attributed to the local release of vascular permeability factor in tumor tissue[3,4].
Localization (release) of vascular permeability factor associated with malignant neoplastic disease, cancer and solid tumor
5) Confidence 0.34 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.72 Pain Relevance 0
Malignant glioma cells release vascular endothelial growth factor (VEGF), an important regulator and promoter of angiogenesis [4].
Localization (release) of vascular endothelial growth factor associated with glioma
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 0.96 Pain Relevance 0.11
They also secrete trophic factors such as vascular endothelial growth factor (VEGF) [54], nerve growth factor (NGF), and BDNF [55].
Localization (secrete) of vascular endothelial growth factor in nerve associated with nerve growth factor
7) Confidence 0.22 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.16 Pain Relevance 0.16
The liver suffers increased cholangiocyte apoptosis, impaired cholangiocyte proliferation, decreased cholangiocyte vascular endothelial growth factor (VEGF) secretion and the disappearance of the peribiliary plexus.
Localization (secretion) of vascular endothelial growth factor in liver associated with apoptosis
8) Confidence 0.18 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.19 Pain Relevance 0.12
Vascular endothelial growth factor (VEGF) is an angiogenic factor released by cells in response to certain stressors, including hypoxia.
Localization (released) of Vascular endothelial growth factor associated with hypoxia
9) Confidence 0.17 Published 2010 Journal J Mol Neurosci Section Body Doc Link PMC2825316 Disease Relevance 0.78 Pain Relevance 0.03
Mechanistically it appears that cord blood CD34 cells mediate effects in part through secretion of glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF) [95].


Localization (secretion) of vascular endothelial growth factor in blood
10) Confidence 0.15 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2989319 Disease Relevance 0.39 Pain Relevance 0.14
COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum.
Localization (secretion) of permeability in duodenum
11) Confidence 0.03 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11668025 Disease Relevance 0 Pain Relevance 0.56

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