INT124435

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) plasma membrane (Chrna9) DNA binding (Creb1)
Anatomy Link Frequency
spinal 3
Chrna9 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 8 100.00 Very High Very High Very High
allodynia 5 98.60 Very High Very High Very High
Dorsal horn 1 84.52 Quite High
intrathecal 1 74.60 Quite High
Neuropathic pain 1 53.04 Quite High
IPN 1 47.84 Quite Low
agonist 1 45.56 Quite Low
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 98.60 Very High Very High Very High
Targeted Disruption 1 75.00 Quite High
Injury 1 58.00 Quite High
Inflammatory Pain 1 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the increased expression of the alpha5 nAChR subunit following SNL contributes to spinal CREB phosphorylation and the maintenance of mechanical allodynia.
Gene_expression (expression) of nAChR in spinal Positive_regulation (contributes) of Phosphorylation (phosphorylation) of CREB in spinal associated with allodynia and spinal nerve ligature
1) Confidence 0.11 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15652389 Disease Relevance 0.60 Pain Relevance 1.17

General Comments

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