INT124438

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.50
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
neurons 4
Macrophage 2
5-HT neurons 2
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 153 99.80 Very High Very High Very High
spastic colon 3 97.64 Very High Very High Very High
Raphe 20 93.40 High High
depression 147 92.60 High High
fluoxetine 75 88.08 High High
Desipramine 1 85.60 High High
monoamine 41 83.40 Quite High
medulla 17 78.32 Quite High
antidepressant 89 65.40 Quite High
Inflammation 2 61.24 Quite High
Disease Link Frequency Relevance Heat
Sudden Infant Death Syndrome 6 97.88 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 97.64 Very High Very High Very High
Inflammatory Bowel Disease 3 97.32 Very High Very High Very High
Congenital Anomalies 11 96.28 Very High Very High Very High
Handedness 48 94.56 High High
Death 4 93.36 High High
Depression 163 92.60 High High
Nociception 1 92.12 High High
Acidosis 57 91.44 High High
Syndrome 4 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that reduced SERT function (via pharmacological blockade) significantly alters GI motility and sensitivity in mice, and support the concept that altered SERT expression and function could contribute to symptoms associated with IBS and IBD.
Regulation (altered) of Gene_expression (expression) of SERT associated with inflammatory bowel disease and spastic colon
1) Confidence 0.62 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16700726 Disease Relevance 0.44 Pain Relevance 0.38
Macrophage activation with lipopolysaccharide had no effect on expression of SERT mRNA or protein.
Neg (no) Regulation (effect) of Gene_expression (expression) of SERT mRNA in Macrophage
2) Confidence 0.62 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15652409 Disease Relevance 0 Pain Relevance 0.34
However, not much is known about the regulation of the transient Sert expression in non-aminergic neurons.
Regulation (regulation) of Gene_expression (expression) of Sert in neurons
3) Confidence 0.52 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.57
In order to find common mechanisms for the regulation of Sert expression conserved through evolution, we used the Vista browser to align sequences upstream of the 5?
Regulation (regulation) of Gene_expression (expression) of Sert
4) Confidence 0.52 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Together with previous results, these findings demonstrate that Zic2 controls specifically the refinement of ipsilateral but not contralateral axons in the primary visual targets by controlling directly the expression of Sert.


Regulation (controlling) of Gene_expression (expression) of Sert
5) Confidence 0.38 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.17 Pain Relevance 0.24
The results presented here support this hypothesis and point to Zic2 as the first transcription factor that regulates Sert expression and serotonin homeostasis in non-aminergic neurons during development.


Regulation (regulates) of Gene_expression (expression) of Sert in neurons associated with serotonin
6) Confidence 0.38 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.63
Alterations of 5-HT metabolism, number of 5-HT neurons, SERT expression and 5-HT receptors expression have been reported in SIDS and a subset of SIDS infants has genetic polymorphisms impacting the 5-HT system [14], [18]–[20].
Regulation (Alterations) of Gene_expression (expression) of SERT in 5-HT neurons associated with sudden infant death syndrome
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 1.27 Pain Relevance 0.13
It has been reported that the expression level of 5-HTT from the 5-HTT gene is influenced by polymorphisms in the 5'-flanking region (5-HTT gene-linked polymorphic region, 5-HTTLPR) and in the variable number tandem repeat (VNTR) of the second intron [11,12].
Regulation (influenced) of Gene_expression (expression) of 5-HTT
8) Confidence 0.09 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.69 Pain Relevance 0.34
It has been reported that the expression level of 5-HTT from the 5-HTT gene is influenced by polymorphisms in the 5'-flanking region (5-HTT gene-linked polymorphic region, 5-HTTLPR) and in the variable number tandem repeat (VNTR) of the second intron [11,12].
Regulation (influenced) of Gene_expression (expression) of 5-HTT
9) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.69 Pain Relevance 0.34

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