INT12444

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 4.70
Pain Relevance 11.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrd)
Anatomy Link Frequency
boutons 2
neuronal 1
PAG 1
neurons 1
cortex 1
Gabrd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
isoflurane 11 100.00 Very High Very High Very High
lidocaine 3 100.00 Very High Very High Very High
cINOD 11 99.88 Very High Very High Very High
Hippocampus 38 99.84 Very High Very High Very High
pregabalin 156 99.82 Very High Very High Very High
agonist 47 99.76 Very High Very High Very High
anesthesia 19 99.58 Very High Very High Very High
gABA 360 99.44 Very High Very High Very High
Glutamate receptor 12 99.24 Very High Very High Very High
Sumatriptan 10 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 74 100.00 Very High Very High Very High
Cluster Headache 2 99.66 Very High Very High Very High
Urological Neuroanatomy 7 99.54 Very High Very High Very High
INFLAMMATION 12 99.26 Very High Very High Very High
Cv Unclassified Under Development 122 98.76 Very High Very High Very High
Bordatella Infection 3 98.04 Very High Very High Very High
Convulsion 44 94.24 High High
Neurogenic Inflammation 2 93.92 High High
Drug Induced Neurotoxicity 6 93.28 High High
Epilepsy 47 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results support earlier binding studies and extend them by demonstrating electrophysiologically a potent quinolone/NSAID drug interaction at the GABAA receptor.
GABAA receptor Binding (interaction) of associated with cinod
1) Confidence 0.48 Published 1991 Journal J. Antimicrob. Chemother. Section Abstract Doc Link 1647389 Disease Relevance 0.14 Pain Relevance 0.51
The anesthetic actions of halothane (fluothane) are thought to be due, at least in part, to an interaction with GABAA receptors.
GABAA Binding (interaction) of associated with halothane
2) Confidence 0.48 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7566654 Disease Relevance 0.17 Pain Relevance 0.39
The results suggest that fenbufen, indomethacin and naproxen in the presence of quinolones may induce the epileptogenic neurotoxicities via pharmacological interaction with GABAA receptor.
GABAA receptor Binding (interaction) of
3) Confidence 0.37 Published 1991 Journal Brain Res. Section Abstract Doc Link 1663416 Disease Relevance 0.21 Pain Relevance 0.66
The mean pixel intensity corresponding to GABAA receptor ?
GABAA receptor Binding (corresponding) of
4) Confidence 0.31 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.07 Pain Relevance 0.13
In order to confirm that the punctate labeling seen with the GABAA receptor ?
GABAA receptor Binding (seen) of
5) Confidence 0.31 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.11 Pain Relevance 0.06
In the PAG, a region involved in mediating panic-like anxiety, alpha4, beta1 and delta GABAA receptor subunits are located principally on GABAergic interneurones.
GABAA Binding (mediating) of in PAG associated with gabaergic, anxiety disorder and urological neuroanatomy
6) Confidence 0.30 Published 2006 Journal Exp. Physiol. Section Abstract Doc Link 16740643 Disease Relevance 0.50 Pain Relevance 0.42
The (+)-stereoisomer of isoflurane produced greater increases in the duration of the IPSC than the (-)-isomer when applied at approximately equal concentrations, suggesting that there is a structurally selective site of interaction for isoflurane that modulates the GABAA receptor. 5.
GABAA Binding (interaction) of associated with isoflurane
7) Confidence 0.29 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 7506753 Disease Relevance 0 Pain Relevance 0.34
Comparison of the structure-activity relationship data obtained in this study with those for steroid-induced general anesthesia strongly suggests that steroidal anesthesia may result from the interaction between steroids and the GABAA receptor.
GABAA receptor Binding (interaction) of associated with anesthesia
8) Confidence 0.28 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3033209 Disease Relevance 0 Pain Relevance 0.28
A stringent structure-activity relationship exists for these interactions of steroids with the GABAA receptor complex.
GABAA receptor Binding (interactions) of
9) Confidence 0.28 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3033209 Disease Relevance 0 Pain Relevance 0.26
It is therefore likely that most (if not all) glycinergic boutons in the superficial dorsal horn use GABA as a co-transmitter, which explains the high proportion of VGAT-immunoreactive terminals that were associated with GABAA ?
GABAA Binding (associated) of in boutons associated with gaba and dorsal horn
10) Confidence 0.27 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.05 Pain Relevance 0.56
By using confocal microscopy on material processed with an antigen-retrieval method, we were able to demonstrate that >95% of VGAT-immunoreactive boutons were associated with at least one GABAA ?
GABAA Binding (associated) of in boutons
11) Confidence 0.27 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.07 Pain Relevance 0.38
This autoradiographic study examines regional GABAA receptors in lidocaine-kindled rats. [35S]t-Butylbicyclophosphorothionate (TBPS), which binds in or near the chloride channel, was used to radiolabel GABAA complexes.
GABAA Binding (binds) of associated with lidocaine
12) Confidence 0.26 Published 1993 Journal Metab Brain Dis Section Abstract Doc Link 8190042 Disease Relevance 0.09 Pain Relevance 0.27
Diazepam (DZP), PB and PGN all enhanced the IGABA by increasing the apparent affinity of the GABAA receptors to GABA.
GABAA Binding (affinity) of associated with gaba
13) Confidence 0.26 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189117 Disease Relevance 0 Pain Relevance 0.27
The neurotoxic effects of 4-quinolones alone and in combination with certain non-steroidal anti-inflammatory drugs (NSAIDs) may be related to an interaction at GABAA and/or ionotropic glutamate receptors.
GABAA Binding (interaction) of associated with inflammation, glutamate receptor and cinod
14) Confidence 0.14 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8788959 Disease Relevance 0.10 Pain Relevance 0.44
This interaction between the GABAA receptor and actin might explain the difference between anaesthesia and physiological neuronal inhibition.


GABAA receptor Spec (might) Binding (interaction) of in neuronal
15) Confidence 0.14 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 12631044 Disease Relevance 0 Pain Relevance 0
METHODS: To compare propofol and GABA, their interaction with the GABAA receptor beta subunit and actin were studied in three cellular fractions of cultured rat neurons using Western blot technique.
GABAA receptor Binding (interaction) of in neurons
16) Confidence 0.14 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 12631044 Disease Relevance 0 Pain Relevance 0
These include drugs enhancing GABAA receptor action through a direct interaction with the receptor (benzodiazepines, barbiturates, propofol, stiripentol, topiramate, carbamazepine, phenytoin, felbamate) or indirectly by increasing the available GABA (tiagabine, vigabatrine, gabapentin, valproate) [51, 90, 156, 199, 251].
GABAA receptor Binding (interaction) of associated with gaba, gabapentin and carbamazepine
17) Confidence 0.12 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.52 Pain Relevance 0.28
Both compounds also enhanced agonist-stimulated activity of the GABAA receptor complex at concentrations near those that impaired movement (<3 ?
GABAA receptor Binding (activity) of associated with agonist
18) Confidence 0.10 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2917171 Disease Relevance 0 Pain Relevance 0.16
Alternatively, the ability of high concentration 1 to block the GABAA complex (Figure 5) may indicate the recruitment of additional, low affinity sites within this ion channel because of the electrophysiological signature for channel blockade at high (lethal) concentrations.
GABAA Binding (complex) of
19) Confidence 0.09 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2917171 Disease Relevance 0 Pain Relevance 0.16
Pertussis toxin reduced the inhibitory effects of both sumatriptan and 5-CT, but not of muscimol, known to act at GABAA receptors.
GABAA Binding (act) of associated with sumatriptan and bordatella infection
20) Confidence 0.07 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9144644 Disease Relevance 0.19 Pain Relevance 0.79

General Comments

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