INT124475

Context Info Confidence 0.04 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.68 Pain Relevance 0.33

mitochondrion (MAP2K1, CPOX) cytoplasm (MAP2K1, CPOX) small molecule metabolic process (CPOX) Golgi apparatus (MAP2K1) cytosol (MAP2K1) signal transduction (MAP2K1)

MAP2K1 (Homo sapiens) CPOX (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 4 92.56 COX-2 inhibitor 1 82.36

Disease Link Frequency Relevance Heat Apoptosis 5 96.32 Colon Cancer 4 75.00 Death 1 66.92 Polyps 1 54.56 INFLAMMATION 1 50.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, MEK/ERK and p38 MAPK activation mediate COX-2 induction by sulindac sulfide.

MEK Positive_regulation (mediate) of Positive_regulation (induction) of COX

1) Confidence 0.04 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15657353 Disease Relevance 0.68 Pain Relevance 0.33

General Comments

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