INT124487

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
nucleus accumbens 2
brain 2
astrocytes 2
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 4 100.00 Very High Very High Very High
Dopamine 2 97.88 Very High Very High Very High
antagonist 1 96.76 Very High Very High Very High
imagery 5 96.24 Very High Very High Very High
Hippocampus 1 95.28 Very High Very High Very High
Morphine 1 84.28 Quite High
Central nervous system 19 77.16 Quite High
aspirin 8 51.20 Quite High
cva 23 50.00 Quite Low
Inflammation 18 50.00 Quite Low
Disease Link Frequency Relevance Heat
Infarction 24 100.00 Very High Very High Very High
Embolism 21 100.00 Very High Very High Very High
Targeted Disruption 12 99.98 Very High Very High Very High
Stroke 64 99.62 Very High Very High Very High
Urological Neuroanatomy 1 93.48 High High
Apoptosis 11 93.32 High High
Neurodegenerative Disease 6 90.44 High High
Middle Cerebral Artery Infarction 35 64.52 Quite High
INFLAMMATION 18 50.00 Quite Low
Cv General 3 Under Development 13 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The METH-induced increase in tPA mRNA expression in the nucleus accumbens was completely inhibited by pre-treatment with R(+)-SCH23390 and raclopride, dopamine D1 and D2 receptor antagonists, respectively.
Negative_regulation (inhibited) of Gene_expression (expression) of tPA mRNA in nucleus accumbens associated with nucleus accumbens, dopamine and antagonist
1) Confidence 0.43 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.09 Pain Relevance 0.48
In this study, we show for the first time that MSCs also enhance neurite outgrowth, which benefits brain recovery after stroke, by concomitantly decreasing the expression of the tPA inhibitor PAI-1 and increasing the activity of tPA in astrocytes in the peri-infarct area of ischemic brain.
Negative_regulation (decreasing) of Gene_expression (expression) of tPA in brain associated with stroke
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 1.02 Pain Relevance 0
To verify the neurite outgrowth promoting effect of tPA secreted by astrocytes, the siRNA technique was used to knock-down the tPA expression in astrocytes.
Negative_regulation (down) of Gene_expression (expression) of tPA in astrocytes associated with targeted disruption
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.37 Pain Relevance 0
CBF was measured before embolic infarction (100% baseline), after embolic infarction, and at 0, 1, 3, and 24 h after injection of t-PA or SMTP-7 in accordance with the manufacturer's instructions.
Negative_regulation (measured) of Gene_expression (injection) of t-PA associated with embolism and infarction
4) Confidence 0.15 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2926440 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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