INT124488

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 5.46
Pain Relevance 6.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
nucleus accumbens 11
striatum 5
brain 4
ear 4
parenchymal cell 2
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 40 100.00 Very High Very High Very High
Morphine 39 100.00 Very High Very High Very High
cva 4 99.12 Very High Very High Very High
Nicotine 4 98.80 Very High Very High Very High
ischemia 20 98.52 Very High Very High Very High
addiction 17 98.12 Very High Very High Very High
Hippocampus 4 97.76 Very High Very High Very High
narcan 1 94.24 High High
Dopamine 21 93.68 High High
Antinociceptive 1 92.00 High High
Disease Link Frequency Relevance Heat
Stroke 108 99.70 Very High Very High Very High
Urological Neuroanatomy 28 99.68 Very High Very High Very High
Hemorrhage 4 99.12 Very High Very High Very High
Cv General 4 Under Development 4 98.52 Very High Very High Very High
Drug Dependence 17 98.12 Very High Very High Very High
Targeted Disruption 25 98.08 Very High Very High Very High
Middle Cerebral Artery Infarction 68 96.76 Very High Very High Very High
Pressure And Volume Under Development 54 92.96 High High
INFLAMMATION 67 90.20 High High
Skin Cancer 2 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the nucleus accumbens of morphine- or methamphetamine-dependent rats were significantly increased compared with those in control animals.
Positive_regulation (increased) of Gene_expression (expression) of tissue plasminogen activator in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.70 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.26 Pain Relevance 0.56
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Positive_regulation (induced) of Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
2) Confidence 0.69 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.43
The acute effect of morphine in inducing tPA expression was diminished after repeated administration.
Positive_regulation (inducing) of Gene_expression (expression) of tPA associated with morphine
3) Confidence 0.68 Published 2006 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 16619846 Disease Relevance 0.09 Pain Relevance 1.11
Treatment of stroke with MSCs significantly increased tPA expression and decreased PAI-1 expression compared with PBS treatment. tPA activity in the MCAo control brain extract and in the MCAo MSC treated brain extract was measured using zymography.
Positive_regulation (increased) of Gene_expression (expression) of tPA in brain associated with middle cerebral artery infarction and stroke
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.84 Pain Relevance 0
An increase of parenchymal cell expression of tPA early after stroke may be a negative factor for neural cell survival and for sustaining blood-brain barrier (BBB) integrity.
Positive_regulation (increase) of Gene_expression (expression) of tPA in parenchymal cell associated with stroke
5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.96 Pain Relevance 0.16
A single morphine treatment induces tPA mRNA and protein expression in the NAc.
Positive_regulation (induces) of Gene_expression (expression) of tPA in NAc associated with nucleus accumbens and morphine
6) Confidence 0.51 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411702 Disease Relevance 0 Pain Relevance 0.83
A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the nucleus accumbens of morphine- or methamphetamine-dependent rats were significantly increased compared with those in control animals.
Positive_regulation (increased) of Gene_expression (expression) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
7) Confidence 0.50 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.26 Pain Relevance 0.56
Single and repeated morphine treatment as well as repeated methamphetamine treatment induced tPA mRNA expression in the nucleus accumbens, which was associated with an increase in the enzyme activity.
Positive_regulation (induced) of Gene_expression (expression) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
8) Confidence 0.50 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.25 Pain Relevance 0.71
The defects of morphine-induced hyperlocomotion as well as methamphetamine-induced locomotor sensitization in tPA-/- mice were reversed by microinjection of exogenous tPA or plasmin into the nucleus accumbens.
Positive_regulation (microinjection) of Gene_expression (microinjection) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
9) Confidence 0.50 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.21 Pain Relevance 0.72
Fig. 3d shows the tPA level was substantially down regulated by transfecting astrocytes with tPA siRNA.
Positive_regulation (transfecting) of Gene_expression (transfecting) of tPA in astrocytes
10) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.46 Pain Relevance 0
Stroke significantly increased expression of tPA and PAI-1 in the ischemic hemisphere compared to non-ischemic brain (Fig. 4a, 4b).
Positive_regulation (increased) of Gene_expression (expression) of tPA in brain associated with stroke
11) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.75 Pain Relevance 0
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Positive_regulation (induced) of in nucleus accumbens Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
12) Confidence 0.24 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.43
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Positive_regulation (induced) of in hippocampus Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
13) Confidence 0.24 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.43
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Positive_regulation (induced) of in frontal cortex Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
14) Confidence 0.24 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.43
The thickness of each ear was measured using a micrometer (Mitutoyo Series IP65, Mitutoyo America, Aurora, IL) before and at 4 h and 24 h after TPA administration.
Positive_regulation (after) of Gene_expression (administration) of TPA in ear
15) Confidence 0.22 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2267461 Disease Relevance 0.36 Pain Relevance 0.05
Thirty minutes after the application of TPA, the inner and outer surface of each ear was treated (10 ?
Positive_regulation (treated) of Gene_expression (application) of TPA in ear
16) Confidence 0.22 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2267461 Disease Relevance 0.33 Pain Relevance 0.04
Resveratrol inhibited the TPA-induced expression of c-Fos and c-Jun in mouse skin, also by inhibiting MAP kinases [18,19].
Positive_regulation (induced) of Gene_expression (expression) of TPA in skin
17) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.30 Pain Relevance 0.07

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