INT124489

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2006
Negated 4
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.48
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
striatum 5
nucleus accumbens 1
frontal cortex 1
hippocampus 1
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 15 100.00 Very High Very High Very High
Nucleus accumbens 23 99.48 Very High Very High Very High
Hippocampus 4 99.20 Very High Very High Very High
narcan 1 95.12 Very High Very High Very High
Antinociceptive 1 92.00 High High
Dopamine 13 88.32 High High
antagonist 4 83.84 Quite High
Central nervous system 4 80.28 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 98.30 Very High Very High Very High
Targeted Disruption 1 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Neg (not) Regulation (affect) of Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
1) Confidence 0.45 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.44
The acute effect of morphine in inducing tPA expression was diminished after repeated administration.
Regulation (effect) of Gene_expression (expression) of tPA associated with morphine
2) Confidence 0.27 Published 2006 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 16619846 Disease Relevance 0.09 Pain Relevance 1.11
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Neg (not) Regulation (affect) of in nucleus accumbens Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
3) Confidence 0.15 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.44
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Neg (not) Regulation (affect) of in hippocampus Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
4) Confidence 0.15 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.44
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Neg (not) Regulation (affect) of in frontal cortex Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
5) Confidence 0.15 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.44

General Comments

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