INT12451

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Context Info
Confidence 0.46
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.86
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefm) cytoskeleton (Nefm)
Anatomy Link Frequency
nerve 2
plasma 1
neuromuscular junctions 1
Nefm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 12 97.04 Very High Very High Very High
Kinase C 10 95.08 Very High Very High Very High
Spinal cord 10 93.92 High High
induced neuropathy 7 86.08 High High
Neuropeptide 1 85.36 High High
Calcitonin gene-related peptide 1 81.40 Quite High
substance P 1 79.92 Quite High
qutenza 4 78.48 Quite High
cerebral cortex 2 74.92 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 4 91.56 High High
Neurodegenerative Disease 1 86.80 High High
Overactive Bladder 7 86.40 High High
Poisoning 2 81.04 Quite High
Neuropathic Pain 8 75.00 Quite High
Overflow Incontinence 1 55.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Except for that of NF-M in CC, the PRs of NF-L, NF-M and NF-H were also elevated in nerve tissues, which was consistent with the activation of protein kinases.
Positive_regulation (elevated) of NF-M in nerve
1) Confidence 0.46 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.13 Pain Relevance 0.92
Except for that of NF-M in CC, the PRs of NF-L, NF-M and NF-H were also elevated in nerve tissues, which was consistent with the activation of protein kinases.
Positive_regulation (elevated) of NF-M in nerve
2) Confidence 0.33 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.13 Pain Relevance 0.93
Rats were all killed after 8 weeks to evaluate the levels of neurofilament(NF)-L, NF-M, NF-H, beta-actin, alpha-tubulin, beta-tubulin, tau, MAP2 proteins in plasma using both SDS-PAGE and western blotting.
Positive_regulation (levels) of NF-M in plasma
3) Confidence 0.32 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.06
At the same level, neurofilament protein immunostaining revealed striking accumulations of neurofilament protein-like material in motor end-plates, thus indicating that neuromuscular junctions of the urethral striated sphincter were severely affected.
Positive_regulation (accumulations) of neurofilament protein in neuromuscular junctions
4) Confidence 0.20 Published 1991 Journal Neuroscience Section Abstract Doc Link 1647505 Disease Relevance 0.35 Pain Relevance 0.35

General Comments

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