INT12453

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Context Info
Confidence 0.35
First Reported 1990
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) extracellular region (Penk)
lipid particle (Sigmar1) endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1)
Anatomy Link Frequency
nucleus accumbens 2
neurons 2
Sigmar1 (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 3 99.00 Very High Very High Very High
fortral 4 96.00 Very High Very High Very High
agonist 1 83.76 Quite High
Enkephalin 3 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrate that sigma-receptor activity can exert tonic effects on proenkephalin mRNA expression in the striatum and the nucleus accumbens of the rat.
sigma-receptor Regulation (effects) of Gene_expression (expression) of proenkephalin in nucleus accumbens associated with nucleus accumbens
1) Confidence 0.35 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1647506 Disease Relevance 0 Pain Relevance 0.43
The data suggest that sigma receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons.
sigma receptor Regulation (affects) of Gene_expression (expression) of proenkephalin in neurons
2) Confidence 0.25 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1968844 Disease Relevance 0 Pain Relevance 0

General Comments

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