INT124548

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.22
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
neuronal 4
T cell 2
Cxcr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 28 98.52 Very High Very High Very High
Endogenous opioid 2 95.52 Very High Very High Very High
Analgesic 2 94.36 High High
chemokine 205 92.20 High High
Sciatic nerve 30 83.44 Quite High
Lasting pain 16 74.44 Quite High
Demyelination 94 71.20 Quite High
Peripheral nervous system 2 63.76 Quite High
antagonist 28 56.40 Quite High
Antinociceptive 2 55.16 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 42 98.52 Very High Very High Very High
Nervous System Injury 56 87.28 High High
Pain 52 74.44 Quite High
Demyelinating Disease 96 71.20 Quite High
Injury 28 61.20 Quite High
Disease 3 60.40 Quite High
INFLAMMATION 13 50.00 Quite Low
Neuropathic Pain 34 5.00 Very Low Very Low Very Low
Nociception 28 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The signaling pattern of IP-10 and CXCR3 receptors in the DRG differs in some respects as there is appreciable basal neuronal expression of both CXCR3 receptors and IP-10.
Negative_regulation (appreciable) of Gene_expression (expression) of CXCR3 in neuronal
1) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.64 Pain Relevance 0.86
The signaling pattern of IP-10 and CXCR3 receptors in the DRG differs in some respects as there is appreciable basal neuronal expression of both CXCR3 receptors and IP-10.
Negative_regulation (appreciable) of Gene_expression (expression) of CXCR3 in neuronal
2) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.58 Pain Relevance 0.78
A second group of AID, which included VD(3), HC and DMF, suppressed mainly type-1 T cell responses, as revealed by strong interference with IFN-gamma production and CXCR3 expression, and limited effects on either or both IL-5 and CCR4 expression.
Negative_regulation (interference) of Gene_expression (expression) of CXCR3 in T cell
3) Confidence 0.11 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15663561 Disease Relevance 0 Pain Relevance 0

General Comments

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