INT124556

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.20
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Adora1) plasma membrane (Adora1) signal transducer activity (Adora1)
Anatomy Link Frequency
spinal 2
Adora1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 11 100.00 Very High Very High Very High
Peripheral nerve injury 4 100.00 Very High Very High Very High
depression 2 100.00 Very High Very High Very High
allodynia 1 100.00 Very High Very High Very High
Morphine 6 99.98 Very High Very High Very High
intrathecal 3 99.80 Very High Very High Very High
Pain 2 99.58 Very High Very High Very High
ischemia 11 98.48 Very High Very High Very High
anesthesia 3 87.20 High High
antagonist 2 53.60 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 4 100.00 Very High Very High Very High
Depression 2 100.00 Very High Very High Very High
Neuropathic Pain 1 100.00 Very High Very High Very High
Cv General 4 Under Development 9 98.48 Very High Very High Very High
Hypersensitivity 1 97.12 Very High Very High Very High
Cv Unclassified Under Development 1 56.48 Quite High
Transient Ischemic Attack 1 26.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor.
Negative_regulation (reduces) of Positive_regulation (activation) of A1 adenosine receptor in spinal associated with adenocard, nervous system injury, allodynia, peripheral nerve injury, morphine and intrathecal
1) Confidence 0.51 Published 2005 Journal Anesthesiology Section Title Doc Link 15681960 Disease Relevance 0.48 Pain Relevance 1.25
Here we tested in vivo whether synaptic depression by adenosine A1 receptor (A1R) activation contributes to BS patterns following GCI.
Spec (whether) Negative_regulation (depression) of Spec (whether) Positive_regulation (activation) of adenosine A1 receptor associated with adenocard, depression and ischemia
2) Confidence 0.34 Published 2009 Journal Neuroscience Section Abstract Doc Link 19344634 Disease Relevance 0.72 Pain Relevance 0.56
CONCLUSION: ICV and IT administration of adenosine agonist R-PIA produced an antinociceptive effect in a dose-dependent manner and decreased halothane MAC with painful stimulation through activation of A1 receptor subtype, and the underlying mechanism involves K+ channel activation.


Negative_regulation (decreased) of Positive_regulation (activation) of A1 receptor
3) Confidence 0.20 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15663896 Disease Relevance 0 Pain Relevance 0

General Comments

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