INT12456

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Context Info
Confidence 0.37
First Reported 1991
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.35
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
hypothalamic nucleus 2
Adra2a (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 8 99.70 Very High Very High Very High
analgesia 5 98.80 Very High Very High Very High
Catecholamine 1 97.84 Very High Very High Very High
Opioid 9 97.72 Very High Very High Very High
Pain 6 90.36 High High
Raphe magnus 2 84.76 Quite High
antagonist 3 80.88 Quite High
agonist 6 75.00 Quite High
Hyperalgesia 3 75.00 Quite High
Analgesic 1 74.08 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 5 94.00 High High
Low Back Pain 1 90.36 High High
Amnesia 2 84.36 Quite High
Aids-related Complex 1 81.04 Quite High
Hypertension 2 80.48 Quite High
Nociception 1 76.64 Quite High
Pain 5 75.76 Quite High
Hyperalgesia 3 75.00 Quite High
Cognitive Disorder 1 75.00 Quite High
Pheochromocytoma 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rat, activation of alpha2-adrenergic receptors in the anterior hypothalamic nucleus inhibits sympathetic nervous system activity.
Negative_regulation (inhibits) of Positive_regulation (activation) of alpha2-adrenergic in hypothalamic nucleus
1) Confidence 0.37 Published 2003 Journal Hypertension Section Abstract Doc Link 12623961 Disease Relevance 0.40 Pain Relevance 0.03
These results indicate that clonidine and guanabenz impaired memory processes in a mouse passive avoidance paradigm through the selective activation of the alpha2A-adrenoceptor subtype.
Negative_regulation (impaired) of Positive_regulation (activation) of alpha2A-adrenoceptor associated with clonidine
2) Confidence 0.31 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15265636 Disease Relevance 0.30 Pain Relevance 0.66
This release is inhibited by activation of alpha 2-adrenergic and muscarinic receptors; the underlying molecular mechanism is not known.
Negative_regulation (inhibited) of Positive_regulation (activation) of 2-adrenergic
3) Confidence 0.01 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1647665 Disease Relevance 0.07 Pain Relevance 0.11
Blockade of the excitatory alpha1-receptor or activation of the inhibitory alpha2-receptor significantly attenuated the analgesia induced by local opioid application, suggesting that alpha1-receptor-mediated synaptic inputs in these primary cells contribute to their excitation during opioid analgesia.
Negative_regulation (Blockade) of Positive_regulation (activation) of alpha2-receptor associated with opioid and analgesia
4) Confidence 0.00 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12944526 Disease Relevance 0.58 Pain Relevance 1.61

General Comments

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