INT124569

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.25
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HPD) small molecule metabolic process (HPD) Golgi apparatus (HPD)
endoplasmic reticulum (HPD) cellular nitrogen compound metabolic process (HPD)
Anatomy Link Frequency
hypothalamus 5
preoptic area 1
ovary 1
HPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 45 99.60 Very High Very High Very High
Morphine 12 95.36 Very High Very High Very High
Kappa opioid receptor 2 88.08 High High
Endogenous opioid 5 78.16 Quite High
Opioid 6 78.08 Quite High
drug abuse 2 70.04 Quite High
cytokine 29 33.44 Quite Low
opiate 2 25.00 Low Low
Inflammation 12 21.28 Low Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 55 98.22 Very High Very High Very High
Mycobacterial Infection 70 90.56 High High
Stress 5 84.48 Quite High
Drug Dependence 2 70.04 Quite High
Latent Tuberculosis 6 50.00 Quite Low
INFLAMMATION 13 21.28 Low Low
Lymphatic Filariasis 7 5.00 Very Low Very Low Very Low
Worm Infection 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Autoimmune Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To detect PPD mRNA, an ovine PPD mRNA was subcloned by reverse transcription-polymerase chain reaction from sheep hypothalamus and used to create a (35)S-labeled riboprobe for in situ hybridization.
Transcription (detect) of PPD in hypothalamus
1) Confidence 0.15 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.08 Pain Relevance 0.40
Neurons that expressed PPD mRNA and DYN A immunoreactivity were widely distributed in the ovine preoptic area and hypothalamus.
Transcription (expressed) of PPD in hypothalamus associated with dynorphin
2) Confidence 0.15 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.07 Pain Relevance 0.41
To detect PPD mRNA, an ovine PPD mRNA was subcloned by reverse transcription-polymerase chain reaction from sheep hypothalamus and used to create a (35)S-labeled riboprobe for in situ hybridization.
Transcription (detect) of PPD in hypothalamus
3) Confidence 0.15 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.08 Pain Relevance 0.40
In this study, we determined the distribution of PPD mRNA and DYN A-containing cell bodies in the brains of ovary-intact, luteal ewes.
Transcription (distribution) of PPD in ovary associated with dynorphin
4) Confidence 0.15 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.08 Pain Relevance 0.38
Neurons that expressed PPD mRNA and DYN A immunoreactivity were widely distributed in the ovine preoptic area and hypothalamus.
Transcription (expressed) of PPD in preoptic area associated with dynorphin
5) Confidence 0.05 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.07 Pain Relevance 0.41
To determine the impact of coexisting filarial infection on baseline and antigen-specific TLR expression of PPD+ individuals, and because filarial infection is associated with diminished expression of TLR1, 2, 4, and 9 [3], we examined the mRNA expression of these TLRs from PPD+Fil?
Spec (examined) Transcription (expression) of PPD associated with infection
6) Confidence 0.02 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.72 Pain Relevance 0
Several weeks later, quantitative RT-PCR was used to determine mRNA expression within the MBH in diestrus, never pregnant (nulliparous) controls, postpartum day 5 (PPD5), PPD10, PPD18, and diestrus, reproductively experienced (primiparous) females.
Spec (determine) Transcription (expression) of PPD18 in MBH
7) Confidence 0.00 Published 2008 Journal Brain Res. Section Abstract Doc Link 18083149 Disease Relevance 0.07 Pain Relevance 0.66
Several weeks later, quantitative RT-PCR was used to determine mRNA expression within the MBH in diestrus, never pregnant (nulliparous) controls, postpartum day 5 (PPD5), PPD10, PPD18, and diestrus, reproductively experienced (primiparous) females.
Spec (determine) Transcription (expression) of PPD10 in MBH
8) Confidence 0.00 Published 2008 Journal Brain Res. Section Abstract Doc Link 18083149 Disease Relevance 0.07 Pain Relevance 0.66

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