INT124570

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 6.76
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HPD) small molecule metabolic process (HPD) Golgi apparatus (HPD)
endoplasmic reticulum (HPD) cellular nitrogen compound metabolic process (HPD)
Anatomy Link Frequency
preoptic area 2
hypothalamus 1
hair 1
anterior 1
skin 1
HPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 63 99.60 Very High Very High Very High
Endogenous opioid 7 81.56 Quite High
Inflammation 72 60.40 Quite High
cytokine 174 59.36 Quite High
abdominal pain 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 420 100.00 Very High Very High Very High
Infection 330 99.24 Very High Very High Very High
Stress 7 87.88 High High
Eczema 12 84.00 Quite High
Allergic Dermatitis 20 83.60 Quite High
Asthma 4 80.80 Quite High
Gastritis 4 80.16 Quite High
Renal Failure 4 79.28 Quite High
Vertigo 4 78.08 Quite High
Hypersensitivity 32 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PPD was found in all the black henna samples (11 samples) with concentration ranging between 0.38 % and 29.5%.
Gene_expression (found) of PPD
1) Confidence 0.78 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872353 Disease Relevance 0 Pain Relevance 0
The study showed that PPD was present in all of the black henna samples at concentrations ranging between 0.4% and 29.5% and higher than that recommended for hair dyes in most of the black henna samples.
Gene_expression (present) of PPD in hair
2) Confidence 0.60 Published 2010 Journal International Journal of Environmental Research and Public Health Section Abstract Doc Link PMC2872353 Disease Relevance 0.24 Pain Relevance 0
Individuals may be occupationally exposed to PPD during its manufacture or use, and the exposure may occur through inhalation, skin and/or eye contact, and ingestion [3–5].
Gene_expression (exposed) of PPD in skin
3) Confidence 0.59 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872353 Disease Relevance 0.84 Pain Relevance 0
For red henna samples, PPD was not detected in nine samples and for the remaining five red henna samples the concentration of PPD was very low, ranging between 0.005% and 0.23%.
Neg (not) Gene_expression (detected) of PPD
4) Confidence 0.52 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872353 Disease Relevance 0 Pain Relevance 0
Although DYN is involved in a number of hypothalamic functions in the sheep, little is known regarding the localization of preprodynorphin (PPD) expression and its major product DYN A (1-17).
Gene_expression (expression) of PPD associated with dynorphin
5) Confidence 0.21 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.09 Pain Relevance 0.39
In this study, we determined the distribution of PPD mRNA and DYN A-containing cell bodies in the brains of ovary-intact, luteal ewes.
Gene_expression (distribution) of PPD in ovary associated with dynorphin
6) Confidence 0.19 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.08 Pain Relevance 0.38
Neurons that expressed PPD mRNA and DYN A immunoreactivity were widely distributed in the ovine preoptic area and hypothalamus.
Gene_expression (expressed) of PPD in hypothalamus associated with dynorphin
7) Confidence 0.19 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.07 Pain Relevance 0.41
PPD mRNA-expressing cells were seen in the supraoptic nucleus, paraventricular nucleus, preoptic area, anterior hypothalamus area, bed nucleus of the stria terminalis, ventromedial nucleus (VMN), dorsomedial nucleus of the hypothalamus, and the arcuate nucleus.
Gene_expression (expressing) of PPD in preoptic area
8) Confidence 0.14 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.07 Pain Relevance 0.41
Neurons that expressed PPD mRNA and DYN A immunoreactivity were widely distributed in the ovine preoptic area and hypothalamus.
Gene_expression (expressed) of PPD in preoptic area associated with dynorphin
9) Confidence 0.06 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.07 Pain Relevance 0.41
PPD mRNA-expressing cells were seen in the supraoptic nucleus, paraventricular nucleus, preoptic area, anterior hypothalamus area, bed nucleus of the stria terminalis, ventromedial nucleus (VMN), dorsomedial nucleus of the hypothalamus, and the arcuate nucleus.
Gene_expression (expressing) of PPD in anterior
10) Confidence 0.05 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.07 Pain Relevance 0.41
PPD mRNA-expressing cells were seen in the supraoptic nucleus, paraventricular nucleus, preoptic area, anterior hypothalamus area, bed nucleus of the stria terminalis, ventromedial nucleus (VMN), dorsomedial nucleus of the hypothalamus, and the arcuate nucleus.
Gene_expression (expressing) of PPD in nucleus
11) Confidence 0.05 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664697 Disease Relevance 0.07 Pain Relevance 0.41
Both baseline (Figure 1A) as well as PPD- (Figure 1B) and Mtb CFP-specific (Figure 1C) induction of TLR2 and 9 was significantly lower in PPD+Fil+ patients (TLR2: geometric mean [GM] of 0.7373 in PPD+Fil+ vs. 0.7973 in PPD+Fil?
Gene_expression (0.7973) of PPD associated with mycobacterial infection
12) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.83 Pain Relevance 0.05
0.0340]; GM fold change of 0.9469 in PPD+Fil+ vs. 2.513 in PPD+Fil?
Gene_expression (2.513) of PPD
13) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.92 Pain Relevance 0.06
0.0340]; GM fold change of 0.9469 in PPD+Fil+ vs. 2.513 in PPD+Fil?
Gene_expression (2.513) of PPD
14) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.92 Pain Relevance 0.06
for PPD [P?
Gene_expression (for) of PPD
15) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.97 Pain Relevance 0.09
Both baseline (Figure 1A) as well as PPD- (Figure 1B) and Mtb CFP-specific (Figure 1C) induction of TLR2 and 9 was significantly lower in PPD+Fil+ patients (TLR2: geometric mean [GM] of 0.7373 in PPD+Fil+ vs. 0.7973 in PPD+Fil?
Gene_expression (lower) of PPD associated with mycobacterial infection
16) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.81 Pain Relevance 0
To determine the impact of coexisting filarial infection on baseline and antigen-specific TLR expression of PPD+ individuals, and because filarial infection is associated with diminished expression of TLR1, 2, 4, and 9 [3], we examined the mRNA expression of these TLRs from PPD+Fil?
Gene_expression (expression) of PPD associated with infection
17) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.70 Pain Relevance 0

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