INT124579

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 30.31
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
apoptotic cells 2
SiHa 1
cleavage 1
pore 1
MCF-7 1
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 60 99.24 Very High Very High Very High
diclofenac 14 98.56 Very High Very High Very High
Paracetamol 25 98.16 Very High Very High Very High
endometriosis 93 97.92 Very High Very High Very High
Kinase C 4 94.16 High High
COX-2 inhibitor 158 88.08 High High
aspirin 16 86.40 High High
cytokine 97 84.16 Quite High
cINOD 113 83.36 Quite High
Inflammation 150 81.20 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1612 99.98 Very High Very High Very High
Lymphatic System Cancer 20 99.36 Very High Very High Very High
Shock 48 99.20 Very High Very High Very High
Death 482 99.04 Very High Very High Very High
Colon Cancer 230 98.28 Very High Very High Very High
Endometriosis 96 97.92 Very High Very High Very High
Stress 163 97.22 Very High Very High Very High
Cancer 881 96.84 Very High Very High Very High
Injury 77 96.64 Very High Very High Very High
Pressure And Volume Under Development 5 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After an apoptotic stimulus, Bax is translocated into the mitochondria and promotes the release of cytochrome c [28], possibly by forming a pore [29] or a voltage-dependent anion channel in the outer mitochondrial membrane.
Localization (translocated) of Bax in pore associated with apoptosis
1) Confidence 0.78 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.94 Pain Relevance 0
Since Bax expression was stimulated only at high resveratrol concentrations while Bax translocation and mitochondria-mediated cell death were observed also at low concentrations, we asked what relevance Bax might have for the chemopreventive activity of the compound.
Localization (translocation) of Bax associated with death
2) Confidence 0.76 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.18 Pain Relevance 0.35
In accord with the sensitivity of HCT116 cells to resveratrol-induced apoptosis, and paralleling the co-localization of Bax to the mitochondria, ??
Localization (localization) of Bax associated with apoptosis
3) Confidence 0.71 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.62 Pain Relevance 0
To study whether the translocation of Bax correlates with ??
Localization (translocation) of Bax
4) Confidence 0.71 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.79 Pain Relevance 0
M resveratrol of human HT29 colon carcinoma cells expressing the dysfunctional p53-273H mutant, HT29 like HCT116 cells showed co-localization of Bax with mitochondria and underwent apoptotic cell death upon drug treatment (data not shown), demonstrating that this effect is not limited to one cell line and is indeed wild-type p53 independent.
Localization (localization) of Bax in apoptotic cell associated with colon cancer, apoptosis and death
5) Confidence 0.71 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.62 Pain Relevance 0.04
Diclofenac induced early (9 h) activation of Bax and Bak and caused mitochondrial translocation of Bax, indicating that MOMP was involved in cell death.
Localization (translocation) of Bax associated with diclofenac and death
6) Confidence 0.70 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18191430 Disease Relevance 0.87 Pain Relevance 0.46
This study focused on the biological mechanisms of sensitivity and resistance to NCX 4040, highlighting that the cytotoxic action of this drug may be due to the hyperexpression of Bax, its translocation to the mitochondria, the release of Cytochrome C, and the activation of caspases-9 and -3, overall in a p53-independent manner.
Localization (translocation) of Bax
7) Confidence 0.68 Published 2006 Journal Apoptosis Section Abstract Doc Link 16699954 Disease Relevance 0.31 Pain Relevance 0.47
In summary, our data thus show that resveratrol at concentrations present in some foods can induce in HCT116 cells i) Bax-dependent, mitochondria-mediated apoptosis, regardless of p53-status and involving Bax co-localization with mitochondria, and ii) Bax-independent, mitochondria-mediated death.
Localization (localization) of Bax-independent associated with apoptosis and death
8) Confidence 0.67 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.79 Pain Relevance 0
However, mitochondria-mediated cell death may also involve down-modulation of Bax-antagonists such as Bcl-XL or Bcl-2 [29], or the translocation of Bax from the cytosol to mitochondria ([30] and discussion therein).
Localization (translocation) of Bax associated with antagonist and death
9) Confidence 0.67 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.07 Pain Relevance 0.09
In summary, our data thus show that resveratrol at concentrations present in some foods can induce in HCT116 cells i) Bax-dependent, mitochondria-mediated apoptosis, regardless of p53-status and involving Bax co-localization with mitochondria, and ii) Bax-independent, mitochondria-mediated death.
Localization (localization) of Bax associated with apoptosis and death
10) Confidence 0.67 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.72 Pain Relevance 0
Curiously, we detected that both bax mRNA abundance and apoptotic cells were increased in early secretory phase in eutopic endometrium from women with endometriosis but not from normal women.
Localization (abundance) of bax in apoptotic cells associated with endometriosis and apoptosis
11) Confidence 0.67 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 1.39 Pain Relevance 0.22
We analyzed apoptosis (TUNEL: DNA fragmentation); cell proliferation (immunohistochemistry (IHC) for Ki67); c-myc, bax and TGF-beta1 mRNA abundance (RT-PCR) and TGF-beta1 protein (IHC) in endometrial explants.


Localization (abundance) of bax associated with apoptosis
12) Confidence 0.67 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1262771 Disease Relevance 0.92 Pain Relevance 0.25
The siRNA for PUMA inhibited the celecoxib-induced activation and translocation of Bax, release of cytochrome c into the cytosol and induction of apoptosis, suggesting that PUMA plays an important role in celecoxib-induced mitochondrial dysfunction and the resulting apoptosis.
Localization (translocation) of Bax associated with parkinson's disease and apoptosis
13) Confidence 0.63 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17368424 Disease Relevance 1.01 Pain Relevance 0.19
AAP-induced apoptosis in HuH7 cells as evidenced by chromatin condensation was preceded by the translocation of Bax to mitochondria and the cytoplasmic release of the proapoptotic factors cytochrome c and Smac/DIABLO.
Localization (translocation) of Bax associated with paracetamol and apoptosis
14) Confidence 0.62 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15665138 Disease Relevance 1.08 Pain Relevance 0.67
m changes, exponentially growing cultures of bax-positive and bax-negative cells were treated with 100 ?
Localization (cultures) of bax-positive
15) Confidence 0.62 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.77 Pain Relevance 0
BH3-only proteins require multidomain pro-apoptotic members Bax and Bak to release cytochrome c from mitochondria and kill cells.
Localization (release) of Bax associated with apoptosis
16) Confidence 0.61 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.66 Pain Relevance 0
Low to moderate concentrations of resveratrol induced co-localization of cellular Bax protein with mitochondria, collapse of the mitochondrial membrane potential, activation of caspases 3 and 9, and finally, apoptosis.
Localization (localization) of Bax protein associated with shock and apoptosis
17) Confidence 0.58 Published 2002 Journal BMC Cancer Section Abstract Doc Link PMC130964 Disease Relevance 1.04 Pain Relevance 0
Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27].
Localization (release) of Bax in B-cell associated with lymphatic system cancer, antagonist and apoptosis
18) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.15 Pain Relevance 0.05
Bcl-2 and Bax localize at the outer membrane of mitochondrial.
Localization (localize) of Bax
19) Confidence 0.56 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.84 Pain Relevance 0
Upon FR122047 treatment, there were apparent increases in the ratio of Bax to Bcl-2, mitochondrial cytochrome c release, and apoptosis in MCF-7 cells.
Localization (release) of Bax in MCF-7 associated with apoptosis
20) Confidence 0.51 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.90 Pain Relevance 0.26

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