INT124583

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.26
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) molecular_function (Elane) cellular_component (Elane)
biological_process (Elane) cytoplasm (Elane)
Anatomy Link Frequency
neutrophil 7
blood 1
Elane (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 31 99.36 Very High Very High Very High
Inflammation 29 94.24 High High
anesthesia 6 92.80 High High
cytokine 9 88.36 High High
Inflammatory response 2 86.40 High High
isoflurane 5 81.28 Quite High
corticosteroid 1 70.52 Quite High
Kinase C 1 53.76 Quite High
fibrosis 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 30 99.36 Very High Very High Very High
Sepsis 7 99.32 Very High Very High Very High
Reperfusion Injury 20 99.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 27 98.64 Very High Very High Very High
INFLAMMATION 41 94.24 High High
Pulmonary Disease 63 84.24 Quite High
Pneumonia 10 80.44 Quite High
Increased Venous Pressure Under Development 1 79.68 Quite High
Coronary Artery Disease 1 76.32 Quite High
Critical Illness 4 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study demonstrate that neutrophil elastase inhibition could effectively attenuate an ischemia-reperfusion injury caused by supraceliac aortic cross-clamping, most likely from the attenuation of neutrophil priming.
Negative_regulation (inhibition) of neutrophil elastase in neutrophil associated with reperfusion injury and ischemia
1) Confidence 0.29 Published 2005 Journal Shock Section Abstract Doc Link 15665731 Disease Relevance 0.62 Pain Relevance 0.29
We discovered that neutrophil elastase inhibition suppressed plasma neutrophil elastase, and that lipid peroxide concentrations increased after reperfusion.
Negative_regulation (inhibition) of neutrophil elastase in neutrophil
2) Confidence 0.29 Published 2005 Journal Shock Section Abstract Doc Link 15665731 Disease Relevance 0.66 Pain Relevance 0.34
In the present study, we use a rabbit model of hepatoenteric ischemia-reperfusion to test the hypothesis that neutrophil elastase inhibition ameliorates an ischemia-reperfusion injury by attenuating neutrophil priming and suppressing enzymatic activity.
Negative_regulation (inhibition) of neutrophil elastase in neutrophil associated with reperfusion injury and ischemia
3) Confidence 0.29 Published 2005 Journal Shock Section Abstract Doc Link 15665731 Disease Relevance 0.56 Pain Relevance 0.30
Furthermore, inhibition of neutrophil elastase with sivelestat significantly attenuated post-reperfusion neutrophil priming.
Negative_regulation (inhibition) of neutrophil elastase in neutrophil
4) Confidence 0.29 Published 2005 Journal Shock Section Abstract Doc Link 15665731 Disease Relevance 0.65 Pain Relevance 0.32
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
Negative_regulation (inhibitor) of neutrophil elastase in neutrophil associated with ischemia
5) Confidence 0.29 Published 2005 Journal Shock Section Title Doc Link 15665731 Disease Relevance 0.65 Pain Relevance 0.32
A synthesized neutrophil elastase inhibitor, sivelestat sodium, may be most effective when used during cardiopulmonary bypass.
Negative_regulation (inhibitor) of neutrophil elastase in neutrophil
6) Confidence 0.17 Published 2008 Journal Interact Cardiovasc Thorac Surg Section Abstract Doc Link 18596053 Disease Relevance 0.25 Pain Relevance 0.13
By week 4 roflumilast had significantly reduced the number of neutrophils and eosinophils (38% and 50%, respectively) and furthermore, there was a concomitant reduction in both neutrophil elastase and IL-8 levels (Grootendorst et al 2005).
Negative_regulation (reduction) of neutrophil elastase in neutrophil
7) Confidence 0.04 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.70 Pain Relevance 0.28
Haemoperfusion reduced levels of plasminogen activator inhibitor-1, neutrophil elastase and interleukin-8 in blood at 48 hours, and improved arterial oxygen tension/fractional inspired oxygen ratio at 96 hours after the start of treatment.
Negative_regulation (reduced) of neutrophil elastase in blood
8) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1550947 Disease Relevance 1.19 Pain Relevance 0.15

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