INT124605

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 7.36
Pain Relevance 5.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Ifih1) nucleus (Ifih1) intracellular (Ifih1)
helicase activity (Ifih1) DNA binding (Ifih1) cytoplasm (Ifih1)
Anatomy Link Frequency
paw 3
gastrocnemius 2
kidney 2
liver 1
Ifih1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 189 99.04 Very High Very High Very High
Paracetamol 33 98.40 Very High Very High Very High
Analgesic 21 95.52 Very High Very High Very High
cytokine 50 93.20 High High
Osteoarthritis 6 87.84 High High
Pain score 2 85.60 High High
Pain 15 85.28 High High
potassium channel 1 82.56 Quite High
qutenza 4 78.76 Quite High
COX-2 inhibitor 2 71.84 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 21 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Cancer 8 100.00 Very High Very High Very High
Urological Neuroanatomy 6 99.80 Very High Very High Very High
INFLAMMATION 187 99.04 Very High Very High Very High
Infection 38 97.36 Very High Very High Very High
Stress 183 91.52 High High
Shock 103 90.48 High High
Aging 12 88.32 High High
Osteoarthritis 2 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production, MDA5?
Gene_expression (production) of MDA5
1) Confidence 0.57 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2443291 Disease Relevance 0.27 Pain Relevance 0.07
The anti-inflammatory mechanism of TC(MeOH) and betulin may be related to decreasing the levels of MDA and NO in the edema paw by increasing the activities of antioxidant enzymes in the liver.
Gene_expression (levels) of MDA in paw associated with pressure and volume under development and inflammation
2) Confidence 0.25 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222115 Disease Relevance 0.80 Pain Relevance 0.33
Tenoxicam-treated patients had significant decrease in nitrite levels (p = 0.036) and XO activity (p = 0.01), but their SOD, GSH-Px enzyme activities, and MDA levels were unchanged from baseline.
Gene_expression (levels) of MDA
3) Confidence 0.24 Published 2005 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15943176 Disease Relevance 0.61 Pain Relevance 0.51
Tenoxicam-treated patients had significant decrease in nitrite levels (p = 0.036) and XO activity (p = 0.01), but their SOD, GSH-Px enzyme activities, and MDA levels were unchanged from baseline.
Gene_expression (activities) of MDA
4) Confidence 0.21 Published 2005 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15943176 Disease Relevance 0.61 Pain Relevance 0.51
In order to study the anti-inflammatory mechanism of MDT, we detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRd) in the liver, the levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF-alpha), malondialdehyde (MDA) and nitric oxide (NO) in the edema paw tissue.
Gene_expression (levels) of MDA in paw associated with pressure and volume under development, necrosis, inflammation and cancer
5) Confidence 0.15 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.04 Pain Relevance 0.46
MDT also affected the levels of interleukin-1beta, tumor necrosis factor-alpha, NO and MDA which were induced by lambda-carrageenan.
Gene_expression (levels) of MDA associated with necrosis and cancer
6) Confidence 0.11 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.34 Pain Relevance 0.59
We also demonstrated that ST1 significantly attenuated the malondialdehyde (MDA) level in the edema paw at 5 h after Carr injection.
Gene_expression (injection) of MDA in paw associated with pressure and volume under development
7) Confidence 0.10 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20507140 Disease Relevance 0.96 Pain Relevance 0.41
AAs afforded a dose-related gastroprotection against the ethanol damage and further prevented the ethanol-induced changes in the levels of GSH, MDA, catalase, SOD and nitrate/nitrite.
Gene_expression (levels) of MDA
8) Confidence 0.08 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19853593 Disease Relevance 0.09 Pain Relevance 0.19
Acetaminophen treatment caused a significant (P < 0.05-0.001) decrease in GSH levels whereas MDA levels and MPO activity were increased in both tissues.
Gene_expression (levels) of MDA associated with paracetamol and urological neuroanatomy
9) Confidence 0.08 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.23 Pain Relevance 0.70
Blood urea nitrogen, serum creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in blood and glutathione (GSH) and malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity and collagen contents in liver and kidney tissues were measured.
Gene_expression (levels) of MDA in kidney associated with urological neuroanatomy
10) Confidence 0.06 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.30 Pain Relevance 0.73
The MDA representation of these ensemble responses was built from five trials for the CS ellipsoid (excluding the tone during the first pairing), for the US ellipsoid from 6 trials of US, and the rest ellipsoid from sampling 14 resting epochs (for matching 7 CS and 7 US epochs).
Gene_expression (representation) of MDA
11) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788416 Disease Relevance 0.09 Pain Relevance 0
Produced MDA forms a stable chromophore which absorbs light at 586 nm (absorbance measured using a spectrophotometer after centrifugation at 8000 g 10 min).
Gene_expression (Produced) of MDA
12) Confidence 0.04 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0 Pain Relevance 0.06
MDA concentrations were expressed as nmol/g wet weight tissue.


Gene_expression (expressed) of MDA
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0 Pain Relevance 0
Figure 3 shows the levels of MDA in kidney tissue homogenates obtained from all the experimental mice.
Gene_expression (levels) of MDA in kidney
14) Confidence 0.04 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.12 Pain Relevance 0
We ascertained that females had significantly higher levels of MDA in the red gastrocnemius (32%, P?
Gene_expression (had) of MDA in gastrocnemius
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.33 Pain Relevance 0
In this study, MDA was higher in CR female red gastrocnemius, most likely due to the greater presence of mitochondria in this highly oxidative tissue [50].
Gene_expression (higher) of MDA in gastrocnemius
16) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.30 Pain Relevance 0
The reaction was standardised with commercial hydrolysed MDA (Merck, Darmstadt, Germany) and the results expressed in nmol of MDA/g of tissue.


Gene_expression (expressed) of MDA
17) Confidence 0.03 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0 Pain Relevance 0.03
Blood urea nitrogen, serum creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in blood and glutathione (GSH) and malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity and collagen contents in liver and kidney tissues were measured.
Gene_expression (levels) of MDA in liver associated with urological neuroanatomy
18) Confidence 0.02 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.30 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox