INT124615

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2005
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.99

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cell proliferation (ENPEP) peptidase activity (ENPEP) cell-cell signaling (ENPEP)
Anatomy Link Frequency
prefrontal 2
ENPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
addiction 4 98.20 Very High Very High Very High
Opioid 4 94.88 High High
Central nervous system 2 92.20 High High
Endogenous opioid 2 88.56 High High
Morphine 2 55.44 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 2 98.20 Very High Very High Very High
Opiate Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we have analyzed the activity of two enkephalin-degrading enzymes (puromycin-sensitive aminopeptidase or PSA and aminopeptidase N or APN) and two functionally different, soluble aminopeptidases (aminopeptidase B and aspartyl-aminopeptidase) in postmortem samples of prefrontal cortex and caudate nucleus of eight human heroin addict brains and eight matched-controls.
Spec (analyzed) Transcription (activity) of aminopeptidase in prefrontal associated with enkephalin
1) Confidence 0.19 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15670637 Disease Relevance 0.10 Pain Relevance 0.46
In the present study, we have analyzed the activity of two enkephalin-degrading enzymes (puromycin-sensitive aminopeptidase or PSA and aminopeptidase N or APN) and two functionally different, soluble aminopeptidases (aminopeptidase B and aspartyl-aminopeptidase) in postmortem samples of prefrontal cortex and caudate nucleus of eight human heroin addict brains and eight matched-controls.
Spec (analyzed) Transcription (activity) of aminopeptidase in prefrontal associated with enkephalin
2) Confidence 0.17 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15670637 Disease Relevance 0.10 Pain Relevance 0.52

General Comments

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