INT124622

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 35
Disease Relevance 21.60
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
Anatomy Link Frequency
colon 4
nerve 2
nucleus 1
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 102 99.84 Very High Very High Very High
dorsal root ganglion 18 97.76 Very High Very High Very High
Morphine 8 96.84 Very High Very High Very High
Endep 2 96.44 Very High Very High Very High
Gabapentin 4 95.72 Very High Very High Very High
Hyperalgesia 20 91.12 High High
allodynia 16 88.92 High High
Inflammation 97 85.04 High High
cytokine 71 79.04 Quite High
c fibre 6 78.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 220 100.00 Very High Very High Very High
Stress 126 100.00 Very High Very High Very High
Nervous System Injury 26 99.88 Very High Very High Very High
Cancer 951 99.84 Very High Very High Very High
Hypoxia 44 99.84 Very High Very High Very High
Colon Cancer 530 99.56 Very High Very High Very High
Colorectal Cancer 4 99.28 Very High Very High Very High
INFLAMMATION 157 99.12 Very High Very High Very High
Lung Cancer 460 98.92 Very High Very High Very High
Dna Damage 14 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this report, we show that ATF3 mRNA and protein expression are up-regulated in HCT-116 human colorectal cancer cells following treatment with NSAIDs, troglitazone, diallyl disulfide, and resveratrol.
Positive_regulation (up-regulated) of ATF3 associated with colorectal cancer and cinod
1) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.50 Pain Relevance 0.26
These compounds induced phosphorylation of extracellular signal-regulated kinase1/2 (Erk1/2), whereas a dominant-negative inhibitor of mitogen-activate protein kinase kinase (MEK) 1 blocked the induction of ATF3.
Positive_regulation (induction) of ATF3
2) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.05 Pain Relevance 0
ATF3 and Egr-1 mRNA and protein and ATF3 promoter activity were induced by these compounds, whereas induction of ATF3 by these compounds was blocked by Egr-1 small interfering RNA.
Positive_regulation (induced) of ATF3
3) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.21 Pain Relevance 0.07
Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide.
Positive_regulation (up-regulated) of ATF3 associated with inflammation, colon cancer and cinod
4) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.10
ATF3 and Egr-1 mRNA and protein and ATF3 promoter activity were induced by these compounds, whereas induction of ATF3 by these compounds was blocked by Egr-1 small interfering RNA.
Positive_regulation (induced) of ATF3
5) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.20 Pain Relevance 0.06
ATF3 and Egr-1 mRNA and protein and ATF3 promoter activity were induced by these compounds, whereas induction of ATF3 by these compounds was blocked by Egr-1 small interfering RNA.
Positive_regulation (induction) of ATF3
6) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.19 Pain Relevance 0.06
Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide.
Positive_regulation (up-regulated) of activating transcription factor 3 associated with inflammation, colon cancer and cinod
7) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.10
ATF3 is a transcription factor involved in cell growth, apoptosis, and invasion and is induced by a variety of anticancer and dietary compounds.
Positive_regulation (induced) of ATF3 associated with apoptosis
8) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.29 Pain Relevance 0.10
Moreover, in a recent publication, Ameri and colleagues could show that induction of ATF3 in hypoxic conditions, a common feature detectable in solid tumors, is independent of the transcription factor HIF-1?
Positive_regulation (induction) of ATF3 associated with hypoxia and solid tumor
9) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.29 Pain Relevance 0
A significant increase in ATF3 can be observed when cell-stress is induced [11], making ATF3 an universal „adaptive response gene" [12,13].
Positive_regulation (increase) of ATF3 associated with stress
10) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.88 Pain Relevance 0
In addition, DIM increased the expression of NAG-1 as well as activating transcription factor 3 (ATF3), and the induction of ATF3 was earlier than that of NAG-1.
Positive_regulation (increased) of activating transcription factor 3
11) Confidence 0.65 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.32 Pain Relevance 0.08
In addition, DIM increased the expression of NAG-1 as well as activating transcription factor 3 (ATF3), and the induction of ATF3 was earlier than that of NAG-1.
Positive_regulation (induction) of ATF3
12) Confidence 0.65 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.31 Pain Relevance 0.08
In addition, DIM increased the expression of NAG-1 as well as activating transcription factor 3 (ATF3), and the induction of ATF3 was earlier than that of NAG-1.
Positive_regulation (increased) of ATF3
13) Confidence 0.65 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.32 Pain Relevance 0.08
Interestingly, induction of ATF3 and IL-24 was highest in M35, a highly responsive MM cell line, and lowest in M25, a poorly responsive cell line, as defined by DNA fragmentation analysis (Figure 4B).


Positive_regulation (induction) of ATF3 associated with lung cancer
14) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 0.53 Pain Relevance 0
Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide.
Positive_regulation (activating) of ATF3 associated with inflammation, colon cancer and cinod
15) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.10
We identified three putative Egr-1 binding sites in the promoter of ATF3 and report for the first time that the molecular mechanism responsible for the transcriptional regulation of ATF3 by two divergent pharmaceutical compounds, sulindac sulfide and troglitazone, involved the early growth response gene-1 (Egr-1).
Positive_regulation (promoter) of ATF3
16) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.26 Pain Relevance 0.08
The MEK1/2 inhibitor PD98059 (2'-amino-3'-methoxyflavone) blocked the induction of ATF3 and Egr-1 mRNA expression and ATF3 promoter activity by these compounds.
Positive_regulation (induction) of ATF3
17) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0 Pain Relevance 0
Since blocking Hsp90 interferes with multiple cell signaling pathways, including MAPK/Erk, PI-3K/Akt, p38 and SAPK, we used in HCT116 cell line selective signaling inhibitors to determine the predominant signaling pathway involved in this Hsp90-inhibitor mediated ATF3 up-regulation (Figure 2).
Positive_regulation (mediated) of ATF3
18) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.59 Pain Relevance 0
Our recent observation that Hsp90 inhibition induces ATF3 in cancer cells and the lack of clarity regarding the biological effect of this transcription factor in oncology pressed our aim to define the role of ATF3 in colon cancer.
Positive_regulation (induces) of ATF3 in colon associated with cancer and colon cancer
19) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.49 Pain Relevance 0
Activating transcription factor 3 (ATF3) was selected for further study because it is a transcription factor involved in cell proliferation, apoptosis, and invasion, and its expression is repressed in human colorectal tumors as compared with normal adjacent tissue.
Positive_regulation (Activating) of ATF3 associated with colorectal cancer and apoptosis
20) Confidence 0.47 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.36 Pain Relevance 0.26

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