INT124624

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 24
Disease Relevance 21.22
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
Anatomy Link Frequency
colon 10
epithelial cells 2
SW620 2
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 61 99.12 Very High Very High Very High
antagonist 14 98.40 Very High Very High Very High
COX-2 inhibitor 28 92.84 High High
Inflammation 4 54.40 Quite High
cytokine 9 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 42 99.78 Very High Very High Very High
Cancer 1129 99.64 Very High Very High Very High
Colon Cancer 718 99.60 Very High Very High Very High
Metastasis 202 99.60 Very High Very High Very High
Colorectal Cancer 12 99.28 Very High Very High Very High
INFLAMMATION 42 98.88 Very High Very High Very High
Hyperplasia 14 98.20 Very High Very High Very High
Shock 112 97.20 Very High Very High Very High
Skin Cancer 15 96.56 Very High Very High Very High
Breast Cancer 42 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of ATF3 in the sense orientation decreased focus formation in vitro and reduced the size of mouse tumor xenografts by 54% in vivo.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ATF3 associated with cancer
1) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.57 Pain Relevance 0.23
Conversely, overexpression of antisense ATF3 was protumorigenic in vitro, however, not in vivo.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ATF3
2) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.58 Pain Relevance 0.21
With microarray analysis, several genes relating to invasion and metastasis were identified by ATF3 overexpression and were confirmed by real-time reverse transcription-PCR, and several of these genes were modulated by sulindac sulfide, which inhibited invasion in these cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ATF3 associated with metastasis
3) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.54 Pain Relevance 0.25
To ascertain the biological significance of ATF3, we overexpressed full-length ATF3 protein in the sense and antisense orientations.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ATF3
4) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.56 Pain Relevance 0.24
Furthermore, overexpression of ATF3 inhibited invasion to a similar degree as sulindac sulfide treatment, whereas antisense ATF3 increased invasion.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ATF3
5) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.44 Pain Relevance 0.15
In this report, we show that ATF3 mRNA and protein expression are up-regulated in HCT-116 human colorectal cancer cells following treatment with NSAIDs, troglitazone, diallyl disulfide, and resveratrol.
Positive_regulation (up-regulated) of Gene_expression (expression) of ATF3 associated with colorectal cancer and cinod
6) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.50 Pain Relevance 0.26
We conclude that ATF3 is likely to be down-regulated in colon cancers, hence supporting the rationale of therapeutically inducing ATF3 expression in this cancer entity.


Positive_regulation (inducing) of Gene_expression (expression) of ATF3 in colon associated with cancer and colon cancer
7) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.55 Pain Relevance 0
In one respect, ATF3 was shown to be overexpressed in human colon cancer specimens and appears to promote tumor growth and migration in an experimental HT29 colon cancer model [18,19].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ATF3 in colon associated with cancer and colon cancer
8) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.57 Pain Relevance 0.12
Thus, drug-induced overexpression of ATF3 may have beneficial effects in only a subset of colon cancer cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ATF3 in colon associated with colon cancer
9) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.49 Pain Relevance 0
Transgenic mice that overexpress ATF3 in basal epithelial cells develop epidermal hyperplasia, dysplastic lesions and oral squamous cell carcinoma [16].
Positive_regulation (overexpress) of Gene_expression (overexpress) of ATF3 in epithelial cells associated with targeted disruption, skin cancer and hyperplasia
10) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.47 Pain Relevance 0
In this study, overexpression of ATF3 inhibited invasion to a similar degree as sulindac sulfide treatment and antisense ATF3 increased invasion in vitro.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ATF3
11) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.02 Pain Relevance 0.15
In addition, DIM increased the expression of NAG-1 as well as activating transcription factor 3 (ATF3), and the induction of ATF3 was earlier than that of NAG-1.
Positive_regulation (increased) of Gene_expression (expression) of ATF3
12) Confidence 0.65 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.32 Pain Relevance 0.08
ATF3 expression increased from 3-fold to more than 400-fold, IL-24 from 2- to nearly 1000-fold, and IL-6 from 2- to nearly 100-fold.
Positive_regulation (increased) of Gene_expression (expression) of ATF3
13) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 0.51 Pain Relevance 0.03
The MEK1/2 inhibitor PD98059 (2'-amino-3'-methoxyflavone) blocked the induction of ATF3 and Egr-1 mRNA expression and ATF3 promoter activity by these compounds.
Positive_regulation (induction) of Gene_expression (expression) of ATF3
14) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0 Pain Relevance 0
The MEK1/2 inhibitor PD98059 (2'-amino-3'-methoxyflavone) blocked the induction of ATF3 and Egr-1 mRNA expression and ATF3 promoter activity by these compounds.
Positive_regulation (induction) of Gene_expression (expression) of ATF3
15) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0 Pain Relevance 0
These results were validated in vivo using a model of subcutaneously implanted gastric (TMK-1), or pancreatic (L3.6pl) cancer cells where Hsp90 inhibitor treatment markedly induced ATF3 expression in respective tumors (Figure 1B).
Positive_regulation (induced) of Gene_expression (expression) of ATF3 associated with cancer
16) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.63 Pain Relevance 0
Importantly, in vitro growth rates of Luc-shRNA and ATF3-shRNA transfected HCT116 cells were statistically not different (data not shown).
Positive_regulation (transfected) of Gene_expression (transfected) of ATF3-shRNA
17) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.21 Pain Relevance 0
In this study, overexpression of ATF3 inhibited invasion to a similar degree as sulindac sulfide treatment and antisense ATF3 increased invasion in vitro.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ATF3
18) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.02 Pain Relevance 0.15
Thus, drug-induced overexpression of ATF3 may have beneficial effects in only a subset of colon cancer cells.
Positive_regulation (induced) of Gene_expression (overexpression) of ATF3 in colon associated with colon cancer
19) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.50 Pain Relevance 0
Indeed we found that blocking Hsp90 induces ATF3 protein expression in human gastric (TMK-1), colon (HT29, HCT116, SW620), and pancreatic (L3.6pl) cancer cell lines (Figure 1A and [8]).
Positive_regulation (induces) of Gene_expression (expression) of ATF3 in SW620 associated with cancer
20) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.64 Pain Relevance 0

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