INT124655

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.32
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
neural 2
neutrophil 1
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 75 100.00 Very High Very High Very High
Inflammation 179 99.34 Very High Very High Very High
addiction 2 99.28 Very High Very High Very High
Morphine 12 99.06 Very High Very High Very High
Inflammatory mediators 2 98.60 Very High Very High Very High
agonist 6 97.96 Very High Very High Very High
withdrawal 12 97.72 Very High Very High Very High
Multiple sclerosis 2 97.68 Very High Very High Very High
Central nervous system 7 93.64 High High
rheumatoid arthritis 13 93.44 High High
Disease Link Frequency Relevance Heat
Adhesions 114 100.00 Very High Very High Very High
INFLAMMATION 188 99.34 Very High Very High Very High
Morphine Dependence 2 99.28 Very High Very High Very High
Disease 144 98.44 Very High Very High Very High
Asthma 31 98.44 Very High Very High Very High
Demyelinating Disease 3 97.68 Very High Very High Very High
Increased Venous Pressure Under Development 12 96.60 Very High Very High Very High
Inflammatory Bowel Disease 81 96.28 Very High Very High Very High
Thyroid Neoplasm 2 96.12 Very High Very High Very High
Pancreatitis 2 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine dependence was also associated with a drastic reduction in the expression levels of the polysialylated form of neural cell adhesion molecule (68% of control), an adhesion molecule expressed by newly generated neurons and involved in cell migration and structural plasticity.
Negative_regulation (reduction) of adhesion molecule in neural associated with addiction, adhesions and morphine
1) Confidence 0.23 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15673448 Disease Relevance 0.63 Pain Relevance 1.09
Morphine dependence was also associated with a drastic reduction in the expression levels of the polysialylated form of neural cell adhesion molecule (68% of control), an adhesion molecule expressed by newly generated neurons and involved in cell migration and structural plasticity.
Negative_regulation (reduction) of adhesion molecule in neural associated with addiction, adhesions and morphine
2) Confidence 0.23 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15673448 Disease Relevance 0.62 Pain Relevance 1.03
potent antiangiogenic action, in vivo, by decreasing CD31, a specific molecular
Negative_regulation (decreasing) of CD31
3) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.79 Pain Relevance 0.08
The MVD was assessed using CD31 and CD34 counts separately.


Negative_regulation (using) of CD31
4) Confidence 0.17 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1435760 Disease Relevance 0.08 Pain Relevance 0
The other, Tysabri, is a laboratory-produced monoclonal antibody which is the first of a new class of agents known as selective adhesion molecule (SAM) inhibitors.
Negative_regulation (inhibitors) of adhesion molecule associated with adhesions
5) Confidence 0.08 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1090568 Disease Relevance 0.92 Pain Relevance 0.14
After a comparable course at different levels in the first 2 days, non-survivors had an increase in adhesion molecule concentrations whereas survivors' adhesion molecule levels decreased markedly.
Negative_regulation (decreased) of adhesion molecule associated with adhesions
6) Confidence 0.04 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.77 Pain Relevance 0
After a comparable course in the first 2 days, non-survivors showed an increase in median values of sELAM-1 and sICAM-1 whereas survivors' adhesion molecule levels decreased markedly (Figs 3 and 4).
Negative_regulation (decreased) of adhesion molecule associated with adhesions
7) Confidence 0.04 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.48 Pain Relevance 0.03
Determination of Serum Cytokines and Soluble Adhesion Molecule Concentrations
Negative_regulation (Determination) of Adhesion Molecule associated with adhesions and cytokine
8) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.18 Pain Relevance 0.05
A second selective adhesion molecule inhibitor, MLN-02, has been demonstrated in a phase 2 study to be efficacious in patients with active ulcerative colitis failing treatment with 5-aminosalicylates.91 A second pilot study was performed in CrohnÂ’s disease with promising effect.92 At this time, it is unknown if the more specific adhesion of this antibody to ?
Negative_regulation (inhibitor) of adhesion molecule associated with inflammatory bowel disease, disease and adhesions
9) Confidence 0.03 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780674 Disease Relevance 1.28 Pain Relevance 0.18
On the molecular level, every other day treatment led to significant declines in vascular cellular adhesion molecule, C-reactive protein, and endothelin-1, all of which are known to be associated with vasoconstriction and/or inflammation.
Negative_regulation (declines) of adhesion molecule associated with inflammation, increased venous pressure under development and adhesions
10) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939761 Disease Relevance 0.50 Pain Relevance 0.05
Furthermore, inflammatory mediators such as intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) were decreased and cyclooxygenase-1 (COX-1) was increased in PAR2-/- mice, suggesting that PAR2 receptors play a pro-inflammatory role.
Negative_regulation (decreased) of adhesion molecule associated with inflammatory mediators, inflammation and adhesions
11) Confidence 0.00 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 1.15 Pain Relevance 0.75
In conclusion, we have found that sTNFR treatment of murine model of acute asthma resulted in reduction of airway inflammation, which was accompanied with the reduction of Th2 cytokine and adhesion molecule.
Negative_regulation (reduction) of adhesion molecule associated with asthma, inflammation, adhesions and cytokine
12) Confidence 0.00 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.16 Pain Relevance 0.27
The mechanisms of action of hypertonic saline are increasingly well understood, and include inhibition of neutrophil adhesion molecule CD11b [5], reduced TNF-?
Negative_regulation (inhibition) of adhesion molecule in neutrophil associated with adhesions
13) Confidence 0.00 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.46 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox