INT124667

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.06
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik2) plasma membrane (Grik2)
Anatomy Link Frequency
SH-SY5Y 1
amygdala 1
synapses 1
Grik2 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 7 100.00 Very High Very High Very High
Anterior cingulate cortex 61 99.10 Very High Very High Very High
Glutamate 4 98.04 Very High Very High Very High
Glutamate receptor 5 97.20 Very High Very High Very High
IPN 4 94.72 High High
qutenza 4 93.88 High High
Lasting pain 9 91.56 High High
Pyramidal cell 31 75.92 Quite High
Inflammation 9 71.04 Quite High
Neuropathic pain 19 44.56 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 13 99.60 Very High Very High Very High
Targeted Disruption 7 99.40 Very High Very High Very High
Inflammatory Pain 4 94.72 High High
Pain 14 91.56 High High
INFLAMMATION 5 71.04 Quite High
Nervous System Injury 17 69.76 Quite High
Neuropathic Pain 29 44.56 Quite Low
Injury 7 17.52 Low Low
Nociception 2 5.00 Very Low Very Low Very Low
Mental Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Xe blocks not only NMDA receptors, but also AMPA and kainate receptors in cortical neurones as well as GluR6-type receptors expressed in SH-SY5Y cells.
Negative_regulation (blocks) of GluR6 in SH-SY5Y
1) Confidence 0.41 Published 2005 Journal Br J Anaesth Section Body Doc Link 15695547 Disease Relevance 0 Pain Relevance 0
Additionally, synaptic potentiation was significantly reduced in the lateral amygdala of GluR6 but not GluR5 knock-out mice.
Neg (not) Negative_regulation (reduced) of GluR6 in amygdala associated with targeted disruption and amygdala
2) Confidence 0.37 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15673679 Disease Relevance 0.80 Pain Relevance 0.56
In classic fear-memory tests, mice lacking GluR6 but not GluR5 showed a significant reduction in fear memory when measured 3, 7, or 14 d after training.
Negative_regulation (lacking) of GluR6 associated with anxiety disorder
3) Confidence 0.32 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15673679 Disease Relevance 0.78 Pain Relevance 0.55
Taking advantage of transgenic and gene knockout mice, recent studies reveal novel molecular and synaptic mechanisms for synaptic transmission and plasticity in the ACC [13,15,27,33,34] For example, using genetic deletion of GluR5, Glur6, or GluR5&6, Wu et al (2005a) demonstrated that glutamate kainate receptor GluR5 and 6 contribute to excitatory synaptic transmission in the synapses of layer II/III ACC.
Negative_regulation (deletion) of Glur6 in synapses associated with targeted disruption, glutamate and anterior cingulate cortex
4) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2807858 Disease Relevance 0.47 Pain Relevance 0.58

General Comments

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