INT124668

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hsd17b12) endoplasmic reticulum (Hsd17b12) extracellular matrix organization (Hsd17b12)
Anatomy Link Frequency
substantia gelatinosa 1
Hsd17b12 (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 57 99.20 Very High Very High Very High
IPN 5 98.80 Very High Very High Very High
Lasting pain 6 97.88 Very High Very High Very High
superficial lamina 1 95.04 Very High Very High Very High
Dorsal horn neuron 5 94.52 High High
amygdala 3 93.32 High High
spinal dorsal horn 5 92.96 High High
gABA 12 92.16 High High
unmyelinated 1 84.72 Quite High
qutenza 4 84.40 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 13 99.16 Very High Very High Very High
Inflammatory Pain 5 98.80 Very High Very High Very High
Pain 7 97.44 Very High Very High Very High
Mental Disorders 2 96.56 Very High Very High Very High
Targeted Disruption 6 94.48 High High
Nociception 7 88.96 High High
Epilepsy 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different kainate receptor (KAR) subtypes contribute to the regulation of both excitatory and inhibitory transmission.
Regulation (regulation) of KAR
1) Confidence 0.42 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15673679 Disease Relevance 0.53 Pain Relevance 0.36
Selectively targeting different KAR subtypes may provide a useful strategy for treating persistent pain and fear-related mental disorders.
Regulation (targeting) of KAR associated with mental disorders, pain, lasting pain and anxiety disorder
2) Confidence 0.26 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15673679 Disease Relevance 1.06 Pain Relevance 0.56
However, it is still unknown whether similar modulation exists in the substantia gelatinosa (SG) of the intact spinal slices and which KAR subunits are involved in the modulation in inhibitory transmission in this region.
Spec (whether) Regulation (involved) of KAR in substantia gelatinosa associated with substantia gelatinosa
3) Confidence 0.12 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.09 Pain Relevance 0.71

General Comments

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